{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:14:58Z","timestamp":1778256898129,"version":"3.51.4"},"reference-count":34,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"abstract":"<jats:p>Introduction: Elevated total tau protein (t-\u03c4) in the cerebrospinal fluid (CSF) is routinely used as a marker of Creutzfeldt-Jakob disease (CJD). We hypothesized that CSF t-\u03c4 and patients\u2019 age may anticipate survival time (ST) also in subjects with familial CJD (f-CJD) as has been shown previously in sporadic CJD (s-CJD). Methods: We analyzed data from the Israeli National CJD Registry from 1991 to 2022. The data included cases of both f-CJD and s-CJD in whom demographic data and CSF t-\u03c4 levels were measured, and the date of death was available. Using X-tile software, we determined the optimal cut-off points for continuous variables in survival analysis and found the cut-points for t-\u03c4 level and patients\u2019 age. Results: We analyzed data on 183 sequential CJD patients. The data included definite (n = 9), probable (n = 165), and possible (n = 9) CJD cases of whom 120 (61 males) were f-CJD (65.6%) and 63 (35 males) patients were s-CJD (34.4%). The cut-off value of CSF t-\u03c4 level was found to be 1,226 pg\/mL. It separated ST into two groups, 105 days (interquartile ranges [IQR]: 59\u2013305) in the lower group vs. 59 days (IQR: 29.5\u2013147.5) in the higher, p = 0.0005. Cox analyses showed that for every 100 pg\/mL increase in CSF t-\u03c4, ST shortened by 3% in days (Exp \u03b2 = 1.0003; 95% confidence interval: 1.0001\u20131.0005). Age had no direct prognostic value but correlated with CSF t-\u03c4 levels (rho = 0.243, p &lt; 0.001). Conclusions: Age and CSF t-\u03c4 levels above the cut-off value predict ST shortening in patients with both f-CJD and s-CJD.<\/jats:p>","DOI":"10.1159\/000551359","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:01:03Z","timestamp":1772730063000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of CSF Total Tau Protein in Patients with Familial and Sporadic Creutzfeldt-Jakob Disease"],"prefix":"10.1159","author":[{"given":"Yacov","family":"Balash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Kahana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Rosenmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurit","family":"Omer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Gilad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anda","family":"Eilam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Appel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos D.","family":"Korczyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00211.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(01)01556-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63545-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200161"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh249"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.25098"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.61186\/nl.2.2.78"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.56.11.1528"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0331-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01045-w"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.648743"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5738-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1071"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1958-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317793"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.08.010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02943-x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1509-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000530407"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0713"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.10.012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12441"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0128-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(97)00215-2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.58.2.192"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1210"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000230159.67128.00"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-133"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.130720"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30477-4"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323826"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70036"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12133"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.875370"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:01:00Z","timestamp":1778256060000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1159\/000551359","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}