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This review aimed to summarize and compare nonprescription treatment options within the context of reflux-like symptom pathophysiology and provide a practical evidence-based tool to help guide tailored treatment selection. Summary: A patient-centered approach should consider the requirement for reactive versus preventative therapies and each product\u2019s unique characteristics. Antacids neutralize refluxed acid in the esophagus, providing temporary relief from occasional heartburn. Raft-forming alginate formulations provide relief of heartburn and regurgitation after meals by forming a viscous gel near the gastroesophageal junction, neutralizing the postprandial acid pocket and coating the esophagus when refluxed. Histamine-2 receptor antagonists reduce gastric acid secretion within 30 min, lasting for up to 12 h, making them useful for treatment and prevention of heartburn, but tachyphylaxis is a limitation. Nonprescription proton pump inhibitors are most effective for preventing frequent acid-related symptoms. They are packaged as a 2-week course for daily use, achieving maximum effect after a few days. Key Messages: Important differences exist among self-management treatment options for reflux-like symptoms. A standardized algorithm is proposed to help tailor treatment selection according to symptom profile. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000551414","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:01:10Z","timestamp":1774371670000},"page":"235-248","source":"Crossref","is-referenced-by-count":0,"title":["Self-Management of Reflux-Like Symptoms: A Patient-Centered Decision-Making Approach"],"prefix":"10.1159","volume":"44","author":[{"given":"A. 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