{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:58:43Z","timestamp":1781197123755,"version":"3.54.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glomerular Dis"],"abstract":"<jats:p>Contactin-1-associated membranous nephropathy is a rare type of membranous nephropathy typically seen in the setting of chronic inflammatory demyelinating polyneuropathy. Here we present a case of a 79-year-old man who presented with ankle edema and was found to have 2,888 milligrams of proteinuria per 24 h and membranous nephropathy on kidney biopsy. Staining for multiple membranous antigens including phospholipase A-2 receptor, NELL-1, and EXT-2 were negative. Liquid chromatography tandem mass spectrometry was performed on glomeruli and identified contactin-1 as the target antigen. Classic secondary causes of membranous nephropathy were excluded including systemic autoimmune disease, malignancies, and medications. Interestingly, the membranous nephropathy occurred 1 month after receiving the last of five doses of mRNA COVID 1273 that occurred over a 19-month period. The patient subsequently underwent spontaneous remission without initiation of disease targeted therapy, suggesting a tentative association between the COVID-19 vaccination and the membranous nephropathy. Additionally, this patient did not have any significant neuropathies typically seen with contactin-1-associated membranous nephropathy. To our knowledge, this is the first case report demonstrating a temporal association between contactin-1-associated membranous nephropathy and vaccination against COVID-19 with mRNA 1273. Our findings in this case broaden the clinical spectrum of the rare contactin-1-associated membranous nephropathy.<\/jats:p>","DOI":"10.1159\/000551432","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:01:25Z","timestamp":1773075685000},"page":"178-183","source":"Crossref","is-referenced-by-count":0,"title":["Contactin-1-Associated Membranous Nephropathy after Multiple mRNA 1273 COVID-19 Vaccinations: A Case Report"],"prefix":"10.1159","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-2147","authenticated-orcid":false,"given":"Jonathan E.","family":"Zuckerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot Parham","family":"Copen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-7781","authenticated-orcid":false,"given":"Stephen","family":"Copen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050522-034537"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020071082"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad227"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.09.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1368457"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.10.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-00980-z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0281156"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.09.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.08.014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2025.578665"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011096"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.11.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102500"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03695-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200365"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095910"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014111061"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070734"}],"container-title":["Glomerular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:00:52Z","timestamp":1781193652000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551432","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31578322","asserted-by":"subject"}]},"ISSN":["2673-3633"],"issn-type":[{"value":"2673-3633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]}}}