{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:48:46Z","timestamp":1782146926231,"version":"3.54.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Introduction: Extranodal natural killer\/T-cell lymphoma, nasal type (ENKTL), is a rare and aggressive malignancy. Primary orbital involvement is exceptionally uncommon. We report a case of orbital ENKTL in a White patient presenting with rapidly progressive orbital symptoms. Case Presentation: A 69-year-old woman presented with eyelid swelling, diplopia, and exophthalmos. An initial diagnosis of conjunctivitis by a community ophthalmologist proved unresponsive to treatment, prompting referral to a tertiary eye center. Orbital magnetic resonance imaging revealed a retrobulbar mass. Biopsy confirmed Epstein-Barr virus-associated ENKTL, and staging excluded systemic disease. The patient received age-adjusted modified SMILE (mSMILE) chemotherapy (dexamethasone, methotrexate, ifosfamide, &lt;sc&gt;l&lt;\/sc&gt;-asparaginase, etoposide) followed by concurrent platinum-based chemoradiotherapy. She achieved complete remission and reported substantial improvement in quality of life. Conclusions: Even exceptionally rare orbital lesions should be considered in cases of rapidly progressive orbital disease. Early imaging, appropriate biopsy, and multidisciplinary management are essential to achieve optimal outcomes.<\/jats:p>","DOI":"10.1159\/000551675","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:00:58Z","timestamp":1779120058000},"page":"553-561","source":"Crossref","is-referenced-by-count":0,"title":["Primary Orbital Extranodal NK\/T-Cell Lymphoma: A European Case Report"],"prefix":"10.1159","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9949-0676","authenticated-orcid":false,"given":"Alexander L.","family":"Rattunde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas M.","family":"M\u00f6hwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina A.","family":"Kunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Schallenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Bertelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2023.11.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.10.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(98)92107-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103237"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9523"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01313-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2016.1228405"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.41"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01319.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13095"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.33"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13761-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.31.8.16221"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2012.736603"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2012.053"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2011.605506"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11237010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0452-9"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:01:23Z","timestamp":1782144083000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551675","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32305707","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]}}}