{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:27:35Z","timestamp":1778642855062,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"abstract":"<jats:p>Introduction: FAT1 is mutated in many types of cancer. The objective of this study was to analyze the diagnostic role of FAT1 protein in cancers affecting the serosal cavities. Methods: FAT1 protein expression by immunohistochemistry was analyzed in 256 effusions (139 peritoneal, 116 pleural, 1 pericardial), consisting of 96 tubo-ovarian carcinomas, 56 breast carcinomas, 44 mesotheliomas, 28 uterine corpus and cervical carcinomas, 15 lung carcinomas, 13 gastrointestinal carcinomas, and 4 cancers of other origin. Results: FAT1 expression was most common in gastrointestinal carcinomas (12\/13; 92%), followed by lung (9\/15; 60%), breast (31\/56; 55%), and uterine cervical (4\/8; 50%) carcinomas, with infrequent expression in other tumors, including tubo-ovarian carcinomas (5\/96; 5%). Mesotheliomas were uniformly negative. Staining of a limited series of surgical specimens showed comparable results for patient-matched breast carcinomas (29\/41; 71%), whereas tubo-ovarian carcinomas were more frequently positive (16\/57; 28%), though often focally, compared to effusions. Eight epithelioid mesotheliomas were negative (0\/8; 0%). Survival analysis for 42 breast carcinoma patients with effusion for whom clinical data were available showed no association with overall (p = 0.398) or disease-free (p = 0.255) survival. Conclusion: FAT1 is commonly expressed in carcinomas of gastrointestinal, lung, or breast origin but is rarely expressed in tubo-ovarian carcinoma effusions and is absent in mesothelioma. Whether this difference is of use in the diagnostic setting remains to be established.<\/jats:p>","DOI":"10.1159\/000551734","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:00:46Z","timestamp":1774630846000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["FAT1 Is Differentially Expressed in Cancers Affecting the Serosal Cavities"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-8427","authenticated-orcid":false,"given":"Ben","family":"Davidson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arild","family":"Holth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9351-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.10.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-010-9315-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12659"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14856"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.11.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.104921"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-020-00195-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-26481-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061397"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1285508"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2024.110808"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116449"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.05.043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1543283"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000326027"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:01:08Z","timestamp":1777478468000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":16,"URL":"https:\/\/doi.org\/10.1159\/000551734","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}