{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:10:21Z","timestamp":1785190221597,"version":"3.55.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"abstract":"<jats:p>Introduction: This study evaluated the trajectory of the urine albumin-to-creatinine ratio (UACR) in patients hospitalized with acute heart failure (HF) from pre-admission (baseline), through hospital admission, discharge and 2 weeks post-discharge. We also assessed its association with congestion-related biomarkers, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), CA 125, and the neutrophil-to-lymphocyte (N\/L) ratio. Methods: Prospective, observational study including 99 consecutive patients admitted with acute HF. Blood and urine analyses were performed at admission, at discharge and 2 weeks post-discharge. Patients were stratified according to UACR at admission and the trajectories of UACR and biomarkers were evaluated. The clinical, analytical, and echocardiographic predictors of UACR were analysed. Results: Mean age was 70.8 \u00b1 12.2 years, 57% were men. At admission, albuminuria was present in 65.7% of patients (45.5% microalbuminuria, 20.2% macroalbuminuria, respectively). A higher UACR at admission was associated with diabetes, lower eGFR, previous HF admission, higher clinical congestion score, mixed or right-sided congestive phenotype, higher NT-proBNP, and CA 125 levels. The UACR worsened from baseline to admission and improved at discharge, reflecting the congestion dynamics. NT-proBNP, CA 125, and N\/L ratio showed similar patterns. Independent predictors of higher UACR at admission were diabetes, reduced renal function, higher aspartate aminotransferase (AST) and lower vitamin D levels. In the mixed linear regression analysis, lower eGFR, and higher AST levels remained independently associated with UACR trajectory. Admission UACR correlated with congestion score and predicted higher in-hospital mortality and early HF readmissions (&lt;30 days). Conclusion: Albuminuria is common in acute HF and exhibits a dynamic change in relation to congestion. These findings suggest a potential role as a biomarker for congestion monitoring. However, given the study limitations, the results should be considered exploratory and warrant confirmation in larger prospective studies.<\/jats:p>","DOI":"10.1159\/000551740","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:03:09Z","timestamp":1775145789000},"page":"258-270","source":"Crossref","is-referenced-by-count":1,"title":["Albuminuria and Acute Heart Failure: A New Biomarker for Congestion and Follow-Up?"],"prefix":"10.1159","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-5850","authenticated-orcid":false,"given":"Mario","family":"Galv\u00e1n-Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Nogueira-Salgueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Rojas-Escriv\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Val","family":"Groba-Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Fern\u00e1ndez-de-Sanmamed-Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas 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