{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:45:11Z","timestamp":1782751511754,"version":"3.54.5"},"reference-count":21,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Objective: The aim of the study was to analyze the changes in serum inflammatory factors and hemodynamics in women with hypertensive disorder of pregnancy (HDCP) who undergo delivery with epidural anesthesia. Methods: A total of 100 HDCP pregnant women were admitted to our hospital from June 2021 to December 2023 and divided into a control group (conventional delivery, i.e., vaginal delivery without analgesia) and a painless group (delivery with epidural anesthesia, i.e., continuous epidural analgesia), with 50 cases in each group. The levels of serum tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6), as well as hemodynamic parameters including heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO), were measured and compared between the two groups at the following time points: pre-analgesia (T1), full cervical dilation (T2), fetal delivery (T3), and 24-h postpartum (T4). Maternal and neonatal outcomes were also compared between the two groups. Results: The painless group had shorter first, second, and third stages of labor and colostrum time than the control group, and the 1-min APGAR score was higher than that of the control group (p &lt; 0.05). The TNF-\u03b1 and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p &lt; 0.05). The TNF-\u03b1 and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p &lt; 0.05). The fluctuation range of MAP, HR, and CO levels in T2, T3, and T4 in the painless group was smaller than that in the control group (p &lt; 0.05). Conclusion: Delivery with epidural anesthesia for HDCP mothers can reduce perinatal inflammatory factor levels and stabilize hemodynamic parameters.<\/jats:p>","DOI":"10.1159\/000551804","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:00:36Z","timestamp":1776528036000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Delivery with Epidural Anesthesia on Peripartum Serum Inflammatory Factors and Hemodynamics in Women with Gestational Hypertension"],"prefix":"10.1159","author":[{"given":"Fei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qian","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Peng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071653"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-00977-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/J.JOGC.2022.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3233\/CH-232026"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14248"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19754"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00478"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.04.018"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2022-322259"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.045"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0909254"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005905"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2024-105444"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.160546"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1356"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.08.019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080196"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.33280"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2016.09.003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3765-x"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:01:07Z","timestamp":1782748867000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1159\/000551804","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]}}}