{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:57:48Z","timestamp":1781110668013,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Transarterial chemoembolization (TACE) using doxorubicin is an established treatment option for unresectable hepatocellular carcinoma (HCC) in cirrhotic patients. In this case report, we describe a rare occurrence of delayed febrile neutropenia following conventional TACE (C-TACE) with doxorubicin. This complication, while recognized with systemic doxorubicin, is rarely documented in the context of C-TACE. Case Presentation: We present a 53-year-old Bangladeshi man with hepatitis B-related HCC who developed febrile neutropenia 2 weeks following C-TACE with doxorubicin. Indeed, previous C-TACE procedures had also resulted in similar neutropenic episodes, which pointed to the association of C-TACE with doxorubicin and neutropenia. Conclusion: The case brings attention and vigilance to the monitoring for neutropenia in patients receiving C-TACE with doxorubicin, an association rarely currently documented in the literature. Further studies are needed to assess its prevalence and identify risk factors and management strategies for this complication.<\/jats:p>","DOI":"10.1159\/000551850","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:03:31Z","timestamp":1775145811000},"page":"656-661","source":"Crossref","is-referenced-by-count":0,"title":["Uncommon Complication of Transarterial Chemoembolization with Doxorubicin: A Case of Post-TACE Neutropenia in Hepatocellular Carcinoma"],"prefix":"10.1159","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-0290","authenticated-orcid":false,"given":"Muhammed","family":"Hajmusa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutaibah Rida","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdalhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sittna","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-1892","authenticated-orcid":false,"given":"Aladdin","family":"Kanbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-022-03346-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.17998\/jlc.2023.02.08"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1651"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-021-00204-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-006-0097-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e16159"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26898"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21622"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0840-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08233-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911363"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011091"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/biology13050352"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/eci.70132"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2025.03.023"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:01:11Z","timestamp":1781107271000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551850","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31920999","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}