{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:00:38Z","timestamp":1784826038338,"version":"3.55.0"},"reference-count":40,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Introduction: The long-term prognostic value of standard C-reactive protein (CRP) in patients with myocardial infarction is unknown. Methods: Using Danish nationwide registries, we identified patients with a diagnosis of myocardial infarction from 2013 through 2020, who had a CRP measurement \u226424 h of index hospitalization. The primary outcome was death from any cause, and the secondary outcome was hospitalization or outpatient contact for new-onset heart failure. Absolute and relative risks for outcomes according to CRP quartiles at days 0\u201330 and 31\u2013365 were calculated using multivariable Cox regression with average treatment effect modeling, adjusted for demographics and clinical features, including high-sensitivity troponin concentrations. Results: A total of 29,035 patients with myocardial infarction were included. Median CRP was 4 mg\/L, and quartile intervals were quartile 1: &lt;2.9 mg\/L, quartile 2: 2.9 to &lt;4 mg\/L, quartile 3: 4 to &lt;12 mg\/L, and quartile 4: \u226512 mg\/L. At 0\u201330 days, 1,660 patients had died, and 1,861 died between days 31 and 365. The standardized absolute risk of death at both 0\u201330 and 31\u2013365 days was lowest among patients in quartile 1 (0\u201330 days: 2.8%, 31\u2013365 days: 4.1%) and highest among patients in quartile 4 (0\u201330 days: 9.7%, 31\u2013365 days: 9.5%). The standardized relative risks of death increased in a stepwise fashion from quartile 2 to quartile 4 when using quartile 1 as the comparator. Similar findings were observed for heart failure. Conclusion: Among patients with myocardial infarction, higher CRP concentrations were significantly associated with a higher risk of death and incident heart failure.<\/jats:p>","DOI":"10.1159\/000551869","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:01:08Z","timestamp":1780070468000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["C-Reactive Protein and Long-Term Risk of Death in Patients with Myocardial Infarction"],"prefix":"10.1159","author":[{"given":"Julie","family":"Borchsenius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian H.","family":"Kragholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B\u00f8dtker","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Barcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Polcwiartek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Vesterlev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Femerling","family":"Langhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-8862","authenticated-orcid":false,"given":"Caroline","family":"Espersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Frary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monija","family":"Mrgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Mihaela","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Qamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Hecht","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars Valeur","family":"K\u00f8ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-402X","authenticated-orcid":false,"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthiah","family":"Vaduganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-5825","authenticated-orcid":false,"given":"Manan","family":"Pareek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316663873"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa099"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07573-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2012.05.026"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063169"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1288"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.071269"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23749"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012638"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.643114"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001309"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_122_20"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00215-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2023-0086"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169168"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.12.006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad870"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S245060"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.027"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23651"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001303"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.04.025"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012832"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1905061"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1080\/1047322x.1990.10389587"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1707914"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad486"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.037"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2025.101809"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp070"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1159\/000492427"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003911"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:00:55Z","timestamp":1784822455000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":40,"URL":"https:\/\/doi.org\/10.1159\/000551869","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32530140","asserted-by":"subject"}]},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}