{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:55:30Z","timestamp":1781628930055,"version":"3.54.5"},"reference-count":5,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"abstract":"<jats:p>Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder associated with substantial psychiatric comorbidity. Although repetitive and compulsive behaviors are reported in NF1, the risk of body-focused repetitive behaviors is understudied. Methods: We performed a retrospective cohort study using the TriNetX research network (2006\u20132026). On January 14, 2026, individuals with a first recorded diagnosis of NF1 were compared with matched controls. Patients with prior trichotillomania or skin-picking disorder were excluded. Cohorts were balanced using 1:1 propensity score matching for demographics, psychiatric comorbidities, and healthcare utilization. Five-year hazard ratios (HRs) were calculated using Cox proportional hazards models with Bonferroni correction. Results: After matching, 33,841 individuals were included in each cohort. NF1 was significantly associated with increased incidence of trichotillomania over 5 years compared with controls (HR 2.46; 95% CI: 1.43\u20134.22; p &lt; 0.001), which remained significant after Bonferroni correction. No significant association was observed for skin-picking disorder (HR 1.25; 95% CI: 0.65\u20132.40; p = 0.670). In sensitivity analyses adjusting for ADHD, autism, and tic disorders, NF1 remained significantly associated with trichotillomania. Conclusion: We found that NF1 was associated with increased risk of trichotillomania. Increased clinical awareness and screening may help improve recognition and management and improve quality of life.<\/jats:p>","DOI":"10.1159\/000551904","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:01:15Z","timestamp":1775836875000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Increased Risk of Trichotillomania in Neurofibromatosis Type 1: A Retrospective Cohort Study"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-9048","authenticated-orcid":false,"given":"Nuran C.","family":"Golbasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Chalupczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-9304","authenticated-orcid":false,"given":"Shari R.","family":"Lipner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201676"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-12023-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62436"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.20210013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/genes16070843"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:02:21Z","timestamp":1781625741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":5,"URL":"https:\/\/doi.org\/10.1159\/000551904","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]}}}