{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:52:12Z","timestamp":1781887932853,"version":"3.54.5"},"reference-count":50,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"abstract":"<jats:p>Introduction: Bariatric surgery is an established treatment for obesity and has been shown to improve glycaemic control and frequently induces remission of type 2 diabetes mellitus (T2DM). However, the long-term sustainability of remission remains uncertain as relapse may occur over time. This study evaluated short- and long-term remission rates and identified factors associated with remission durability and relapse. Methods: A retrospective cohort study was conducted, which included 186 patients with obesity and type2 diabetes who underwent sleeve gastrectomy (SG) or Roux-en-Y gastric bypass between January 2009 and December 2020 at University Hospital Ayr. Diabetes remission was defined as HbA1c &lt;6.0% without anti-diabetic medication use, assessed at 2 years (short term) and 5 years (long term). Multivariable logistic and Cox regression models were used to identify factors associated with remission and relapse. Results: Two- and 5-year post-surgery remission rates were 57.5% and 36.4%, respectively. Shorter duration of diabetes (OR 0.86, 95% CI 0.76\u20130.96; p = 0.009), lower preoperative HbA1c (OR 0.61, 95% CI 0.43\u20130.87; p = 0.005), and not using anti-diabetic medications before surgery (p &lt; 0.05) were all associated with a higher likelihood of diabetes remission at 2 years. Of 107 patients who achieved remission at 2 years, 33.4% experienced diabetes relapse by 5 years. Age (HR 1.06; 95% CI 1.01\u20131.12; p &lt; 0.015) and use of anti-diabetic medications (p &lt; 0.05) were identified as significant factors associated with diabetes relapse. Conclusion: Bariatric surgery is effective in achieving early remission of T2DM; however, one-third of patients experience relapse within 5 years. A more favourable preoperative metabolic profile and younger age play a crucial role in remission durability. These findings highlight the importance of long-term follow-up and individualised patient counselling on expected diabetes outcomes after bariatric surgery.<\/jats:p>","DOI":"10.1159\/000552002","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:00:50Z","timestamp":1776268850000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Diabetes Remission and Relapse following Sleeve Gastrectomy and Gastric Bypass: A 2- and 5-Year Follow-Up 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