{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:53:30Z","timestamp":1782320010709,"version":"3.54.5"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>Introduction: Mitochondrial diabetes is rare and typically treated with dietary intervention and oral hypoglycaemic agents. Most require insulin. Novel treatments are available but are not well characterised. Case Presentation: A 16-year-old adolescent girl with a genetically confirmed diagnosis of MELAS due to an m.3243A&gt;G variant presented with clinical and biochemical features of diabetes. She was successfully transitioned from subcutaneous insulin therapy to weekly GLP-1RA monotherapy shortly after diagnosis of diabetes. Treatment with 0.25 mg semaglutide SC weekly led to a reduction in HbA1c from 13.7% (126 mmol\/mol) to 5.6% (38 mmol\/mol) over a 7-month period. Insulin was completely ceased within 5 days of starting semaglutide. CGM data from a 11 months follow-up period are presented, which demonstrate CGM data meeting glycaemic targets. Conclusion: Low-dose semaglutide 0.25 mg sc weekly was efficacious and well tolerated without lactic acidosis. Use of GLP-1RA could be considered a novel and effective treatment in the pharmacological management of paediatric mitochondrial diabetes.<\/jats:p>","DOI":"10.1159\/000552014","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:00:43Z","timestamp":1776528043000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon-Like Peptide-1 Receptor Agonists in the Management of Mitochondrial Diabetes in an Adolescent: A Case Report"],"prefix":"10.1159","author":[{"given":"Eadaoin","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Nillsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-3988","authenticated-orcid":false,"given":"Aris","family":"Siafarikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-1735","authenticated-orcid":false,"given":"Mary B.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24362"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21217"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00836.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.951185"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0779-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-024-00556-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.108111"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13426"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-021-01729-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.239.89"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-3007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/a-2436-7723"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12992"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208601"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00246-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1530\/EC-19-0118"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9338-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0981"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.07.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46120872"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.03.143"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.721135"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.21016"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0650"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-1018-z"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2023.107691"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:00:51Z","timestamp":1782316851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1159\/000552014","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]}}}