{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:47:00Z","timestamp":1782406020791,"version":"3.54.5"},"reference-count":20,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>Introduction: Potassium-competitive acid blockers (P-CABs) have been empirically administered to treat non-esophageal eosinophilic gastrointestinal diseases, although their efficacy remains unproven. Our previous findings demonstrated that psychological stress impairs the intestinal barrier and exacerbates eosinophilic enteritis (EoN) in a mouse model. Moreover, we demonstrated that P-CAB increased intestinal permeability under psychological stress. The aim of this study was to clarify the hypothesis that P-CAB exacerbate EoN by increasing intestinal permeability under stressful conditions. Methods: An EoN model was established in BALB\/c mice using ovalbumin (OVA) sensitization and challenge. Mice were subjected to water avoidance stress (WAS) or sham stress (SS) and were administered P-CAB or saline as a vehicle. The ileum was collected for the analysis of ileal microscopic inflammation, mRNA and protein expression levels of T helper type 2 (Th2) cytokines, and ex vivo ileal permeability using a Ussing chamber. Results: Compared with the WAS + vehicle group, WAS + P-CAB significantly exacerbated the incidence of diarrhea, villus\/crypt ratio, eosinophil and mast cell counts, mRNA and protein levels of Th2 cytokines, OVA-specific immunoglobulin E protein levels, and ileal permeability. Larazotide acetate, a zonulin inhibitor, significantly improved ileal inflammation and decreased ileal permeability in the WAS + P-CAB-treated EoN mice. Conclusions: P-CAB increased ileal permeability and exacerbated EoN under stressful conditions. Furthermore, a zonulin inhibitor demonstrated therapeutic effects in EoN with P-CAB under stressful conditions.<\/jats:p>","DOI":"10.1159\/000552062","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:01:08Z","timestamp":1776700868000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Potassium-Competitive Acid Blocker Increases Ileal Permeability and Exacerbates Ileal Inflammation under Stress Conditions in a Mouse Model of Eosinophilic Enteritis"],"prefix":"10.1159","author":[{"given":"Kei","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-1249","authenticated-orcid":false,"given":"Fumio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ominami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nadatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-6415","authenticated-orcid":false,"given":"Koji","family":"Otani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusei","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-5672","authenticated-orcid":false,"given":"Shuhei","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001658"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.02.017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8417-21"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000228"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.041"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13841"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158538"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2512"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103315"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac168"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00386.2020"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19785"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac823"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08326-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3170fje"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.1.0008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1023\/a:1015827908309"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.13025"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:01:19Z","timestamp":1782403279000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":20,"URL":"https:\/\/doi.org\/10.1159\/000552062","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32052522","asserted-by":"subject"}]},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}