{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:56:01Z","timestamp":1781801761801,"version":"3.54.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Esophageal leiomyomas are rare benign smooth-muscle tumors, usually small and incidentally detected; giant lesions in young adults are uncommon and may mimic malignant disease when symptomatic. This case highlights the unusual presentation of a giant mid-esophageal leiomyoma in a young adult and the diagnostic challenge of distinguishing large benign intramural tumors from malignant disease. Case Presentation: A 22-year-old male Syrian patient with celiac disease presented with an 18-month history of progressive dysphagia, worsening over the preceding 6 months, with associated unintentional weight loss. Upper gastrointestinal endoscopy showed a submucosal lesion at 25 cm from the incisors with intact mucosa. Contrast-enhanced chest CT demonstrated a heterogeneous intramural mid-esophageal mass at the level of the carina, extending approximately 11 cm, causing mild luminal narrowing without evidence of metastatic disease. The patient underwent elective right-sided video-assisted thoracoscopic enucleation through three ports. The mass was successfully enucleated from the mid-esophageal wall, and a chest drain was placed. Histopathology revealed an encapsulated spindle-cell neoplasm without atypia or mitotic activity; immunohistochemistry supported leiomyoma and excluded malignancy. Conclusion: VATS enucleation achieved definitive diagnosis and symptom resolution with an uncomplicated 3-month outcome. The key message is that giant esophageal leiomyoma, even in young adults, can be effectively managed with minimally invasive esophageal-preserving surgery after careful evaluation.<\/jats:p>","DOI":"10.1159\/000552097","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:00:34Z","timestamp":1776528034000},"page":"720-728","source":"Crossref","is-referenced-by-count":0,"title":["Giant Mid-Esophageal Leiomyoma in a Young Adult Managed by Video-Assisted Thoracoscopic Enucleation: A Case Report"],"prefix":"10.1159","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9600-6326","authenticated-orcid":false,"given":"Mohammad Alaa","family":"Aldakak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1504-3045","authenticated-orcid":false,"given":"Youssef","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamama","family":"Abo Dakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Al Jabban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Dandashy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain","family":"Chaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000548498"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.81614"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.14984"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/a-2615-6193"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.89349"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000543564"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.110746"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.71384"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1489207"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i9.2116"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2024.03.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.108433"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.942371"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1364306"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2025.111257"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/a-2526-2387"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:01:14Z","timestamp":1781798474000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552097","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32049786","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]}}}