{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:52:08Z","timestamp":1782233528492,"version":"3.54.5"},"reference-count":27,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>Objective: This study aimed to evaluate whether a ketogenic diet (KD) mitigates behavioral, metabolic, and peripheral tissue alterations in a rat model of propylthiouracil (PTU)-induced hypothyroidism. Subjects and Methods: Adult female Sprague-Dawley rats (n = 28) were randomly assigned to control, KD, PTU, and KD+PTU groups. Hypothyroidism was induced using 0.05% PTU for 6 weeks, while KD was administered during the final 4 weeks. Behavioral testing was conducted during the final phase of the experimental period, followed by biochemical and histological analyses at the end of the 6-week protocol. Behavioral assessments included the open field, light\/dark box, forced swim, and Morris water maze tests. Biochemical analyses evaluated serum free thyroxine (T4), thyroid-stimulating hormone (TSH), glucose, \u03b2-hydroxybutyrate, tumor necrosis factor alpha (TNF-\u03b1), and interleukin 10 (IL-10). Histological evaluations targeted the thyroid gland, liver, white adipose tissue (WAT), and brown adipose tissue (BAT). Results: PTU significantly reduced serum free T4 levels and impaired spatial learning and mood-related behaviors. KD effectively induced nutritional ketosis and improved systemic glucose metabolism but did not reverse cognitive impairment or depressive-like behaviors associated with hypothyroidism. Histologically, KD attenuated PTU-induced hepatic inflammation, WAT dysfunction, and BAT whitening. Thyroid morphology and circulating TNF-\u03b1 and IL-10 levels remained unchanged across groups. Conclusion: KD exerts favorable metabolic and peripheral tissue effects in PTU-induced hypothyroidism but does not rescue associated neurobehavioral deficits, likely due to persistent thyroid hormone deficiency.<\/jats:p>","DOI":"10.1159\/000552101","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:01:09Z","timestamp":1778256069000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Ketogenic Diet on Behavioral, Metabolic, and Peripheral Tissue Changes in a Propylthiouracil-Induced Hypothyroidism Model"],"prefix":"10.1159","author":[{"given":"Erhan Caner","family":"Akkaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Ilgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"K\u0131z\u0131lda\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"Argon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferda","family":"Ho\u015fg\u00f6rler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0424"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2235"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1111-z"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041599"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910792"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030361"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17885"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.116"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.11.023"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0057"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-008-3274-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00717.2006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2022.109748"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.044"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41977"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1437"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2025.0178"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-023-00396-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21083020"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3795950"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.01.011"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.04.011"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1443483"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415860"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109412"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126364"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:08:10Z","timestamp":1782230890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1159\/000552101","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}