{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:47:53Z","timestamp":1791823673142,"version":"4.3.4"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Introduction: This study aimed to elucidate the clinical attributes of vancomycin-induced linear IgA bullous dermatosis (LABD) to enhance diagnostic, therapeutic, and preventive approaches. Methods: We conducted a retrospective analysis of vancomycin-induced LABD cases by reviewing the literature in Chinese and English databases up to July 31, 2025. Results: A total of 104 patients were identified for the retrospective analysis, with a median age of 70 years (range 29, 92). The median time to onset of LABD was 9 days (range 0.5, 20), with 80.7% of patients presenting symptoms within 2 weeks. The predominant clinical manifestations included blisters (87.1%), vesicles (41.3%), erythema (52.9%), and papules (19.2%), frequently accompanied by pruritus (18.3%). Mucosal involvement was noted in 26.9% of cases. Histopathological examination typically demonstrated inflammatory cell infiltration (79.8%). Direct immunofluorescence assays revealed linear IgA deposition along the basement membrane zone. After stopping vancomycin and receiving treatment, all patients exhibited significant improvement in their skin lesions. Conclusion: Clinicians should recognize LABD as a serious but infrequent adverse reaction to vancomycin. Increased vigilance is crucial during the initial 2 weeks of vancomycin treatment, especially in elderly patients over 60 years of age. LABD recovered completely after withdrawal of vancomycin and other treatments.<\/jats:p>","DOI":"10.1159\/000552120","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:24:48Z","timestamp":1786724688000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics, Treatment, and Outcomes of Vancomycin-Induced Linear IgA Bullous Dermatosis"],"prefix":"10.1159","author":[{"given":"Zhaoquan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2275663"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-025-09000-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.0761"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3154"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000246930"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/med4.47"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13121"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1990"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8975-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700514"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1478318"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2005.tb00839.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70017-a"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12301"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.09.018"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03110.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04492.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12488"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(94)70015-x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199901000-00001"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15244"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.035"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy8020070"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.10.002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1913412"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.36481"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70004-y"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12720"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:16Z","timestamp":1791820936000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1159\/000552120","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]}}}