{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:45:16Z","timestamp":1782751516308,"version":"3.54.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"abstract":"<jats:p>&lt;p&gt;Introduction: Bryophyllum spp. preparations are frequently used in integrative settings. A recent study observed a reduction in anxiety symptoms among a heterogeneous group of psychiatric\/psychosomatic patients after 2 weeks of treatment with Bryophyllum 50% chewable tablets. This secondary analysis aims to identify variables associated with a stronger reduction in anxiety symptoms. Methods: Fifty-four patients with anxiety symptoms were recruited from the waiting list for inpatient care at the \u201cKlinik Arlesheim,\u201d Department of Psychiatry and Psychosomatics, and treated with Bryophyllum 50% chewable tablets (3 \u00d7 2 per day; Weleda AG, Arlesheim, Switzerland). The primary outcome was a change in anxiety symptoms, measured by the Beck Anxiety Inventory (BAI) after 2 weeks of treatment relative to baseline (\u0394BAI). Comparisons were made across subgroups using one-way ANOVA. Multivariate analyses (MVA) were conducted to assess the relative importance of various independent variables, including the depression scale (PHQ-9). Results: BAI score decreased by an average of 5 points (from 27.4 \u00b1 12.0 to 22.4 \u00b1 12.1; p &lt; 0.001, n = 54). \u0394BAI decreased progressively across age quartiles and increased with baseline BAI scores (BAI&lt;sub&gt;bl&lt;\/sub&gt;). Patients on benzodiazepines showed less improvement compared to those who were not. MVA indicated that \u0394BAI was significantly associated with age (inversely) and with BAI&lt;sub&gt;bl&lt;\/sub&gt; (proportionally), after adjusting for other relevant variables. When BAI&lt;sub&gt;bl&lt;\/sub&gt; was excluded from the MVA model, a nonsignificant association was observed between \u0394BAI and PHQ-9. Conclusion: Due to the uncontrolled single-arm design, our findings are exploratory and do not permit causal inferences. Nevertheless, this explorative analysis suggests that younger age and more severe anxiety symptoms were associated with greater reductions in anxiety symptom burden during treatment with Bryophyllum 50% chewable tablets. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000552252","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:01:07Z","timestamp":1777564867000},"page":"191-198","source":"Crossref","is-referenced-by-count":0,"title":["Which Patients with Anxiety Symptoms Benefit Most from Treatment with Bryophyllum pinnatum? A Secondary Analysis of a Prospective, Single-Arm Study"],"prefix":"10.1159","volume":"33","author":[{"given":"Tiffany","family":"Huber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-0403","authenticated-orcid":false,"given":"Daniel","family":"Kr\u00fcerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kr\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schlemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-0952","authenticated-orcid":false,"given":"Ana Paula","family":"Sim\u00f5es-W\u00fcst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-106727"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x1701200847"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2012.087"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-124975"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000487431"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1534735415580680"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.10.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.11.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X261417922"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ph17111423"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.118547"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000095344.32154.d3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.11.053"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-218"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-000850"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2017.08.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-025-00752-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000536015"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-59"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:01:29Z","timestamp":1782748889000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,29]]},"published-print":{"date-parts":[[2026,7,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000552252","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32111500","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}