{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:59:43Z","timestamp":1791907183527,"version":"4.3.4"},"reference-count":24,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Peripherally inserted central catheters (n-PICCs) are standard in neonatal intensive care but carry high complication rates. Ultrasound-guided non-tunneled centrally inserted central catheters (nT-CICCs) offer a potential alternative. This study compared outcomes of nT-CICCs versus n-PICCs in extremely low birth weight (ELBW) neonates. Methods: This is a single-center, comparative cohort study (April 2022\u2013October 2025) enrolling neonates &lt;1,000 g requiring central venous access. A retrospective cohort receiving n-PICCs was compared with a prospective cohort receiving nT-CICCs. The primary outcome was central line-associated bloodstream infection (CLABSI) density rate on successfully placed catheters. Secondary outcomes included procedural success, mechanical complications, and risk factors for CLABSI. Results: We analyzed 103 catheter insertions (50 nT-CICCs, 53 n-PICCs). Procedural success was 100% for nT-CICCs and 94% for n-PICCs (3 immediate failures excluded from follow-up). Among 100 indwelling catheters, nT-CICCs showed significantly lower CLABSI rates (1.83 vs. 11.09 per 1,000 catheter-days; p = 0.038). Overall complications affected 4% of the nT-CICC group versus 64% of the n-PICC group (p &lt; 0.001). nT-CICCs enabled therapy completion in 66% of cases compared with 12% for n-PICCs. Catheter type was the sole independent predictor of CLABSI (adjusted HR 7.1, 95% CI: 1.01\u201349.74; p = 0.048). Conclusions: Ultrasound-guided nT-CICCs are associated with significantly lower rates of infectious and mechanical complications compared with n-PICCs in ELBW neonates. This approach provides a safer and more durable option for central venous access in this vulnerable population.<\/jats:p>","DOI":"10.1159\/000552258","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T16:00:39Z","timestamp":1779552039000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasound-Guided Non-Tunneled Centrally Inserted Central Catheters versus Peripherally Inserted Central Catheters in Neonates under 1,000 Grams: A Comparative Cohort Study"],"prefix":"10.1159","author":[{"given":"Antonella","family":"Capasso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-5859","authenticated-orcid":false,"given":"Fiorentino","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Meliande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Salom\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-1582","authenticated-orcid":false,"given":"Francesco","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819891546"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12700"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820940174"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045895"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04984-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/11297298241239699"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956549"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1129729818804718"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2024-003004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.12.059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05800-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/NHH.0000000000001270"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1645"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2012.03923.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00900-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2017.09.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03663-y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0575-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000002976"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.987512"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/11297298241278385"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/11297298211036002"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:01:05Z","timestamp":1784736065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":24,"URL":"https:\/\/doi.org\/10.1159\/000552258","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]}}}