{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:10:33Z","timestamp":1783959033141,"version":"3.55.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>Introduction: Anti-amyloid therapy has increased the need for noninvasive methods to assess vascular amyloid. Reductions in cerebrospinal fluid (CSF) A\u03b240 and A\u03b242 are characteristic of cerebral amyloid angiopathy (CAA), but lumbar puncture limits their use in routine practice. Magnetic resonance imaging-visible perivascular spaces in the centrum semiovale (CSO-PVS) have emerged as a potential imaging marker, although their relevance in amyloid-positive individuals without CAA-related hemorrhages remains uncertain. Methods: We retrospectively analyzed 30 patients with mild cognitive impairment due to Alzheimer\u2019s disease (AD) or mild AD who exhibited reduced CSF A\u03b242\/40 ratio and no CAA-related hemorrhagic findings. CSO-PVS were visually quantified and dichotomized into high- and low-degree groups using the median raw count. CSF A\u03b240, A\u03b242, and p-tau181 levels were compared between groups. Results: Patients with high-degree CSO-PVS demonstrated significantly lower CSF A\u03b240 levels than those with low-degree CSO-PVS (p = 0.0235), while CSF A\u03b242 showed a borderline reduction (p = 0.0502). The composite index A\u03b240 \u00d7 A\u03b242 was also reduced in the high-degree group (p = 0.0264). CSF p-tau181 levels were significantly lower in the high-degree group than in the low-degree group (p = 0.0264). Conclusion: A higher CSO-PVS burden was associated with lower CSF A\u03b240 and A\u03b242 levels, suggesting that CSO-PVS dilation may serve as a noninvasive surrogate marker of vascular amyloid deposition in amyloid-positive patients undergoing anti-amyloid therapy.<\/jats:p>","DOI":"10.1159\/000552381","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:00:40Z","timestamp":1778688040000},"page":"85-94","source":"Crossref","is-referenced-by-count":0,"title":["Enlarged Centrum Semiovale Perivascular Spaces as a Noninvasive Imaging Marker of Vascular Amyloid Deposition in Amyloid-Positive Individuals without Cerebral Amyloid Angiopathy-Related Hemorrhages"],"prefix":"10.1159","volume":"16","author":[{"given":"Takashi","family":"Kasai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Akazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Kitani-Morii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Naeshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maika","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12366"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12216792"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(22)00208-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21694"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314697"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(16)00070-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2741\/4035"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26610"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000438225.02729.04"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12816"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100150"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.4719"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.10.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.10.017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.43.11.2412-a"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00772.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92823-k"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50873"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0550-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6070-25"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3233\/jad-160400"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021137"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.013"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000550942"}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:01:11Z","timestamp":1783958471000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552381","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32260689","asserted-by":"subject"}]},"ISSN":["1664-5464"],"issn-type":[{"value":"1664-5464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}