{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:39Z","timestamp":1785148359176,"version":"3.55.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Drug-induced acute pancreatitis (DIAP) is a rare cause of acute pancreatitis, accounting for approximately 3\u20135% of cases, and reports of chemotherapy-induced pancreatitis remain limited. Case Presentation: Herein, we present the case of a 68-year-old man who developed DIAP during adjuvant chemotherapy with S-1 plus docetaxel and later with capecitabine plus oxaliplatin following surgery for gastric cancer. A drug-induced lymphocyte stimulation test (DLST) was conducted to identify the suspected agents, yielding positive results for S-1 and capecitabine, whereas docetaxel and oxaliplatin were negative. Unexpectedly, the DLST result for 5-fluorouracil was negative. Based on these findings, adjuvant chemotherapy was switched to 5-fluorouracil plus leucovorin, which was successfully continued without recurrence of pancreatitis. Shortly thereafter, the patient was diagnosed with recurrent gastric cancer. However, palliative chemotherapy with a 5-fluorouracil\u2013based regimen was safely continued. Conclusion: Although DIAP can be fatal, the DLST may help identify the suspected causative drug and contribute to decision-making in important clinical situations such as cancer treatment.<\/jats:p>","DOI":"10.1159\/000552401","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:01:22Z","timestamp":1779379282000},"page":"874-881","source":"Crossref","is-referenced-by-count":1,"title":["Gastric Cancer Treated with 5-Fluorouracil following Discontinuation of Adjuvant S1 plus Docetaxel and Capecitabine plus Oxaliplatin due to Drug-Induced Acute Pancreatitis: A Case Report"],"prefix":"10.1159","volume":"19","author":[{"given":"Yumi","family":"Takamori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Tanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiki","family":"Toriumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemichi","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1367-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i44.16529"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa072252"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01138"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61873-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90689-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.4.565"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.11.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1516493"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijpp.2024.038"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.8.1076.32870"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S88857"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.08.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13076"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000333605"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1c169"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:01:18Z","timestamp":1783440078000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552401","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32251863","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}