{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:44:31Z","timestamp":1793241871684,"version":"4.5.0"},"reference-count":28,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Anaphylaxis is an acute, potentially life-threatening systemic hypersensitivity reaction. Psychological symptoms, including anxiety, depressive symptoms, and post-traumatic stress symptoms (PTSS), may persist after the acute episode; however, adult data remain limited. This study aimed to describe the prevalence and co-occurrence of psychological symptoms after anaphylaxis in adults and to examine their associations with clinical characteristics, acute severity indicators, and epinephrine\/adrenaline auto-injector-related behaviors. Methods: This single-center cross-sectional study included adults with medically confirmed anaphylaxis within the previous 6 months and at least 1 month beyond the index event. Anxiety and depressive symptoms were screened using the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS-A) and the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), respectively. PTSS were assessed using the Post-traumatic Stress Disorder Checklist for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Short Form (PCL-5-S). Thresholds were HADS-A \u226510, HADS-D \u22657, and PCL-5-S \u22656. Positivity on at least one threshold was defined as combined psychological risk. Results: Seventy-five adults were included; the median age was 39 years, and 53.3% were female. The most common triggers were bee venom (38.7%) and drugs (29.3%). According to the World Allergy Organization severity grading system, 57.3% of reactions were classified as grade 4\u20135. Above-threshold symptoms were observed in 14.7% for anxiety, 25.3% for depression, and 37.3% for PTSS; overall, 50.7% met at least one threshold. Psychometric scores were not significantly associated with reaction severity group, intensive care unit admission, or epinephrine\/adrenaline administration. Depression scores differed by trigger type, with higher scores in idiopathic and drug-triggered cases. Conclusion: Psychological symptom burden was common in the early post-anaphylaxis period among adults and did not appear to parallel acute clinical severity. Brief multidomain psychological screening may support more comprehensive post-anaphylaxis follow-up and help identify patients who may benefit from further assessment or referral.<\/jats:p>","DOI":"10.1159\/000552435","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:01:06Z","timestamp":1778515266000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Psychological Symptom Burden after Anaphylaxis in Adults: A Cross-Sectional Study"],"prefix":"10.1159","author":[{"given":"\u015e\u00fckran","family":"Aslan Sava\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"\u00c7\u00f6lkesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-0544","authenticated-orcid":false,"given":"Mehmet 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