{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:24:31Z","timestamp":1783441471241,"version":"3.54.6"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Introduction: Angioid streaks (AS) are a rare retinal disorder that leads to progressive vision loss, particularly when complicated by macular neovascularization (MNV). Anti-vascular endothelial growth factor agents are the first-line treatment for MNV with AS; however, the optimal treatment strategy remains controversial. Herein, we present two cases of type 2 MNV secondary to AS treated with intravitreal faricimab (IVF), the first bispecific antibody, using a treat-and-extend (T&amp;E) protocol over a 1-year follow-up. Case Presentations: Case 1: A 63-year-old male patient achieved dry macula after three monthly IVF injections, with visual acuity (VA) improving from 20\/25 to 20\/16. Subretinal fluid recurred 19 weeks after the loading phase, promoting treatment interval adjustment to 16 weeks. Fluid was subsequently controlled with two additional IVF injections with a 16-week interval. Over 1 year, VA was maintained at 20\/16 with five IVF injections. Case 2: A 78-year-old female patient achieved dry macula with four monthly IVF injections, and VA improved from 20\/32 to 20\/16. The treatment interval was managed despite a recurrence at 16 weeks after the loading phase, leading to seven IVF injections over 1 year. VA remained stable at 20\/16, although pre-existing focal macular atrophy slightly expanded. No subretinal fibrosis or severe ocular complications were observed in both cases. Conclusion: These findings support the efficacy and safety of IVF in the T&amp;E regimen in managing AS-associated type 2 MNV, emphasizing the potential of dual-pathway inhibition for this challenging pathology.<\/jats:p>","DOI":"10.1159\/000552451","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:00:48Z","timestamp":1778860848000},"page":"632-638","source":"Crossref","is-referenced-by-count":0,"title":["Treat-and-Extend Faricimab for Macular Neovascularization in Angioid Streaks: A Report of Two Cases"],"prefix":"10.1159","volume":"17","author":[{"given":"Norihiko","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002327"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/vision8010010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000627"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00010-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31826b0bbe"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01836.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.10.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181cafc75"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.283"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:02:01Z","timestamp":1783440121000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552451","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32284833","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}