{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:11:03Z","timestamp":1784304663198,"version":"3.55.0"},"reference-count":18,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"abstract":"<jats:p>Introduction: While neonates may suffer from alloimmune or secondary autoimmune diseases caused by placental transfer of maternal antibodies, primary neonatal autoimmune disease is extremely rare. Case Presentation: We present a newborn girl with fetal-onset autoimmune disease, featuring prenatal hydrothorax, progressive Coombs-positive autoimmune hemolytic anemia, and autoimmune thrombocytopenia secondary to autoantibodies against glycoprotein IIb\/IIIa, which were not present in the mother. Red blood cells and platelets were repeatedly transfused during the first 5 weeks after birth. At 6 months of life, the infant displayed elevated liver enzymes and vitamin K deficiency coagulopathy due to giant cell hepatitis. There was a partial response to systemic steroids, intravenous immunoglobulins, and anti-CD20 antibodies. Complete genome analysis failed to detect a genetic cause. Conclusion: This rare case indicates that infantile Evans syndrome can already evolve during fetal development.<\/jats:p>","DOI":"10.1159\/000552462","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:00:57Z","timestamp":1779206457000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Fetal-Onset Autoimmune Hemolytic Anemia and Thrombocytopenia Followed by Giant Cell Hepatitis: A Case Report"],"prefix":"10.1159","author":[{"given":"Leonie","family":"Mu\u00dfotter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta Leonore","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holzhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-8405","authenticated-orcid":false,"given":"Beate","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-6667","authenticated-orcid":false,"given":"Christof","family":"Dame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-414X","authenticated-orcid":false,"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0543"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.596386"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.869033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(81)80388-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.050"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2020.03.10"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a98dbe"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2023.1077304"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000548476"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718779783"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60091457"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-024-01029-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel379"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4161\/chim.29844"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164511"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1007927"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6611"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:01:04Z","timestamp":1784304064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1159\/000552462","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32284830","asserted-by":"subject"}]},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}