{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:46:05Z","timestamp":1791996365420,"version":"4.4.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Primary salivary clear cell carcinoma (CCC) is a rare tumor of the minor salivary glands that is often seen as low-grade and responsive to resection. Limited data exist for its response to systemic chemotherapy or immune therapy. Case Presentation: A 76-year-old male presented with recurrent, widely metastatic salivary CCC over 3 years after local resection with bilateral selective neck dissections. Advanced imaging showed biopsy-confirmed metastasis to the omentum, lungs, pleural effusion, and lymph nodes. Stable disease was achieved with carboplatin\/paclitaxel therapy, but treatment was not tolerated by the patient due to side effects. Patient has been treated with single-agent pembrolizumab for 12 cycles with continued disease control and improvement in effusion. Conclusion: Despite the low immunogenicity of this tumor, a clinically positive response was achieved with PD-(L)1 inhibition. More research is needed to identify systemic targeted therapies for CCC and tumors with low immunogenicity.<\/jats:p>","DOI":"10.1159\/000552473","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:01:43Z","timestamp":1789488103000},"page":"1760-1766","source":"Crossref","is-referenced-by-count":0,"title":["Primary Salivary Clear Cell Carcinoma with Response to Checkpoint Inhibition: Case Report and Review of the Literature"],"prefix":"10.1159","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7004-5930","authenticated-orcid":false,"given":"Samuel F.","family":"Schaeffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Mirsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20881"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb01732.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.03.018"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/14394.7867"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105753"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039150"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501824"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2023.100532"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.6797"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-024-01510-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.10.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108707"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15164035"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.08.023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.02.001"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:01:32Z","timestamp":1791993692000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552473","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33772300","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]}}}