{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:32:01Z","timestamp":1786984321871,"version":"build-2736575974"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulse"],"abstract":"<jats:p>Introduction: Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), has been linked to diabetic peripheral neuropathy (DPN). However, the evidence regarding its association with large-nerve fiber dysfunction, specifically assessed by vibration perception threshold (VPT), in Chinese patients aged 18\u201365 years with type 2 diabetes mellitus (T2DM) is scarce. This study aimed to investigate the relationship between baPWV and VPT in this specific population. Methods: This cross-sectional study enrolled 600 inpatients with T2DM aged 18\u201365 years. baPWV was measured using an automated waveform analyzer. DPN was defined as a VPT \u226515 volts in at least one foot. Multivariable logistic regression models were used to assess independent association, expressed as odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic spline and subgroup analyses were performed to evaluate the dose-response relationship and consistency of the association. Results: Among the participants, 165 (27.5%) were classified into the abnormal VPT group. After full adjustment for confounders including age, gender, diabetes duration, glycated hemoglobin, and lifestyle factors, each 100 cm\/s increase in baPWV was significantly associated with increased odds of DPN (OR = 1.07, 95% CI: 1.01\u20131.14). When analyzed by quartiles, participants in the highest baPWV quartile (\u22651,660 cm\/s) had 1.29-fold higher odds of abnormal VPT (OR = 1.29, 95% CI: 1.03\u20133.01) compared to those in the lowest quartile (&lt;1,380 cm\/s), with a significant trend across quartiles (p for trend = 0.005). A linear dose-response relationship was confirmed without evidence of a threshold effect. Subgroup analyses showed the association was consistent across different patient characteristics. Conclusion: Elevated baPWV is independently associated with higher odds of DPN measured by VPT in Chinese patients aged 18\u201365 years with type 2 diabetes. This linear relationship not only underscores the pivotal role of arterial stiffness in the pathogenesis of DPN but also positions baPWV as a valuable tool for early risk stratification in clinical practice.<\/jats:p>","DOI":"10.1159\/000552508","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:01:04Z","timestamp":1783612864000},"page":"119-127","source":"Crossref","is-referenced-by-count":0,"title":["Association between Brachial-Ankle Pulse Wave Velocity and Large-Nerve Fiber Function in Chinese Adults Aged 18\u201365 Years with Type 2 Diabetes"],"prefix":"10.1159","volume":"14","author":[{"given":"Yan","family":"Xuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Leiqun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0097-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30081-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0554"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.657"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.531"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003140"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.07.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3658-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.6.443"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02278.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13515"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3286"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.70008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00041"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11769"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1663-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.11.008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122044"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S535989"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.07.032"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00496-z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-6-139"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212574"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5325.563"}],"container-title":["Pulse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:00:48Z","timestamp":1786982448000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552508","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32937059","asserted-by":"subject"}]},"ISSN":["2235-8676","2235-8668"],"issn-type":[{"value":"2235-8676","type":"print"},{"value":"2235-8668","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}