{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:12:17Z","timestamp":1784045537032,"version":"3.55.0"},"reference-count":21,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<jats:p>Introduction: Hydrogen sulfide (H&lt;sub&gt;2&lt;\/sub&gt;S) is a gaseous signalling molecule with vasodilatory properties and regulates inflammation and fibrosis in the liver. Methods: Rats with bile duct ligation (BDL)-induced liver disease were treated with propargylglycine (PAG; 30 mg\/kg via intragastric gavage), a selective inhibitor of cystathionine \u03b3-lyase, the main source of H&lt;sub&gt;2&lt;\/sub&gt;S in the cardiovascular system and liver, or vehicle. PAG treatment was initiated at day 5 after BDL to evaluate its effects on the progression of liver fibrosis and portal hypertension. Results: In BDL rats, PAG significantly reduced portal pressure (PP) (10.4 \u00b1 2.7 mm Hg versus 16.0 \u00b1 3.9 mm Hg, p &lt; 0.05) without affecting systemic pressure. In mesenteric arteries mounted on a wire myograph, no differences were observed in responses to acetylcholine and H&lt;sub&gt;2&lt;\/sub&gt;S donor sodium hydrosulfide between treated and untreated BDL rats. In the liver, PAG treatment significantly reduced the expression of IL-6, TGF-\u03b2, and collagen I and markedly attenuated hepatic fibrosis and architectural distortion. Rats treated with PAG also exhibited significantly lower alanine aminotransferase. Conclusion: In BDL rats, inhibition of H&lt;sub&gt;2&lt;\/sub&gt;S synthesis decreases PP and attenuates liver fibrosis, suggesting that targeting H&lt;sub&gt;2&lt;\/sub&gt;S may represent a therapeutic strategy for portal hypertension, potentially through modulation of intrahepatic resistance.<\/jats:p>","DOI":"10.1159\/000552592","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:01:02Z","timestamp":1779120062000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of H\n                    <sub>2<\/sub>\n                    S Production Reduces Portal Pressure and Attenuates Liver Fibrosis in Bile Duct-Ligated Rats"],"prefix":"10.1159","author":[{"given":"Raffaele","family":"Buono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Crescenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Brocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-598X","authenticated-orcid":false,"given":"Arben","family":"Dedja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Gasparello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-3196","authenticated-orcid":false,"given":"Marco","family":"Di Pascoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000462974"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9613-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00331.2004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2024.2345477"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118972"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1153"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6773"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2019.08.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025943"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.131"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22037"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5133"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-017-1792-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43536-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00395.2012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182736688"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2017.09.010"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:01:30Z","timestamp":1784044890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1159\/000552592","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]}}}