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Karger AG","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Introduction: The Japanese Coronary Intervention Using Drug-Eluting and Perfusion Therapy for Left Main Disease Registry (JDEPTH-LM Registry) is a prospective, multicenter observational study in 32 Japanese institutions evaluating the double-effect kissing balloon technique (W-KBT) as a novel strategy for left main trunk percutaneous coronary intervention (LM-PCI). This approach combines provisional crossover stenting, proximal optimization technique, KBT, and prolonged (\u226530 s) KBT using a perfusion balloon for the left anterior descending artery and a drug-coated balloon for the left circumflex (LCx) ostium. Methods: A total of 280 patients with stable\/unstable angina or non-ST-elevation myocardial infarction and LCx ostial involvement will be enrolled. The co-primary endpoints are procedural success and major adverse cardiovascular events at 12 months. The JDEPTH-LM Registry will provide clinical data on the safety and efficacy of W-KBT, which may enhance outcomes in LM-PCI involving the LCx ostial lesion. Conclusion: These findings could contribute to the optimization of complex LM-PCI strategies in clinical practice.<\/jats:p>","DOI":"10.1159\/000552600","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T16:00:39Z","timestamp":1779552039000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Double-Effect Kissing Balloon Technique in Left Main Bifurcation Percutaneous Coronary Intervention: Design and Rationale of Japanese Coronary Intervention Using Drug-Eluting and Perfusion Therapy for Left Main Disease 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