{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:41:59Z","timestamp":1792773719730,"version":"4.5.0"},"reference-count":36,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>Introduction: Pediatric obesity is associated with early metabolic and kidney alterations, and identifying children at increased cardiometabolic risk remains challenging. Cystatin C may reflect both renal and metabolic dysfunction. This study aimed to assess the relationship between cystatin C and measures of adiposity, insulin resistance (IR), and cardiometabolic risk in children with overweight and obesity. Methods: In this retrospective cross-sectional study, 169 children with overweight and obesity were analyzed. Anthropometric, blood pressure, kidney (serum creatinine, cystatin C), glucose\/insulin, and lipid parameters were collected. Participants were stratified by cystatin C tertiles, and variables were compared across groups. Stepwise regression identified independent predictors of cystatin C. Results: In this study, children in the highest cystatin C tertile had higher standard deviation score-body mass index (SDS-BMI), waist circumference (WC), systolic and diastolic BP SDS, and iCARE index \u2013 developed within the Improving Renal Complications in Adolescents with Type 2 Diabetes through REsearch (iCARE) cohort study as a marker of IR and metabolic risk. They also showed elevated Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), fasting glucose-to-insulin ratio, and triglyceride-to-HDL cholesterol ratio, while glucose excursion did not differ. Stepwise regression identified WC and HOMA-IR as independent predictors of cystatin C. Conclusion: Elevated cystatin C in children with overweight and obesity is independently associated with central adiposity and IR, supporting its potential as an integrated early marker of metabolic and kidney risk.<\/jats:p>","DOI":"10.1159\/000552607","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:00:51Z","timestamp":1786464051000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Cystatin C: Not Only a Kidney Marker but Also a Potential Early Indicator of Metabolic Alterations in Childhood Obesity"],"prefix":"10.1159","author":[{"given":"Angelika","family":"Mohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Di 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