{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:02:15Z","timestamp":1785430935535,"version":"3.56.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis Extra"],"abstract":"<jats:p>Introduction: While conventional risk factors fail to fully explain stroke incidence, psychological well-being has emerged as a potential determinant of cerebrovascular health. The aim of this study was to investigate the prospective association between baseline life satisfaction and incident stroke among middle-aged and older Chinese adults. Methods: About 15,225 participants aged \u226545 years were included from the China Health and Retirement Longitudinal Study (CHARLS, 2011\u20132020). Life satisfaction was assessed at baseline using a single-item 5-point scale. Incident stroke was self-reported in follow-up waves. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for sociodemographic factors, lifestyle behaviors, comorbidities, and depression symptoms. Subgroup analyses were performed by age, gender, comorbidities, BMI, and depression symptoms. Results: Over the follow-up of 9 years, 1,296 participants (8.5%) developed stroke. Higher life satisfaction was associated with a significantly reduced risk of stroke (HR: 0.83; 95% CI: 0.72\u20130.95). Subgroup analyses indicated that the protective association was more pronounced among older adults, females, participants with chronic conditions (hypertension, diabetes, heart disease), overweight individuals, and those with depression symptoms. Conclusions: Higher life satisfaction was prospectively associated with a lower risk of incident stroke in middle-aged and older Chinese adults. Given the observational design and reliance on self-reported measures, these findings should be interpreted as evidence of association rather than causation. Future studies incorporating repeated assessments of well-being and clinically verified stroke outcomes are warranted.<\/jats:p>","DOI":"10.1159\/000552659","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T16:00:39Z","timestamp":1779552039000},"page":"171-179","source":"Crossref","is-referenced-by-count":0,"title":["Association between Life Satisfaction and Incident Stroke in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study from the CHARLS"],"prefix":"10.1159","volume":"16","author":[{"given":"Xiuli","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-023-00463-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000475"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040449"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2020.20"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.11.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-025-01225-w"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110414"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0269215520956908"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-059663"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025550"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-14246-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107254"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12712"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000228"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.08.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2020.1834275"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009790"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2020-031"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1484726"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000001030"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720003566"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/eurjcn\/zvaa008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2022.2083703"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2368-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S550771"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-023-01107-4"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-161411"}],"container-title":["Cerebrovascular Diseases Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:00:56Z","timestamp":1785427256000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552659","archive":["Portico"],"relation":{},"ISSN":["1664-5456"],"issn-type":[{"value":"1664-5456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]}}}