{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:10:41Z","timestamp":1783959041702,"version":"3.55.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Dis"],"abstract":"<jats:p>Introduction: This study evaluated the clinicopathological profiles and prognostic trajectories of nondiabetic renal disease (NDRD) subtypes coexisting with type 2 diabetes mellitus (T2D). Methods: The study cohort comprised of 123 patients with predominant NDRD subtypes: IgA nephropathy (T2D-IgAN, n = 52), membranous nephropathy (T2D-MN, n = 48), and podocytopathies (T2D-Podo, n = 23). Multivariate Cox regression was used to identify prognostic factors for renal outcomes over a median follow-up period of 80 months (interquartile range 62\u2013102). Results: T2D-MN patients exhibited distinct characteristics compared to T2D-IgAN and T2D-Podo, including advanced age, higher incidence of nephrotic-range proteinuria and elevated total cholesterol. This group also demonstrated a greater susceptibility to atherosclerotic plaque formation. Pathological analysis revealed more severe glomerular sclerosis, interstitial inflammation, and C3 deposition in T2D-IgAN. Multivariate Cox regression identified three independent predictors of renal endpoints: glomerular C3 deposition (HR 3.021, 95% CI: 1.084\u20138.419), preserved estimated glomerular filtration rate (&gt;60 mL\/min\/1.73 m2; HR 0.296, 95% CI: 0.110\u20130.796), and prolonged T2D duration (&gt;10 years; HR 4.168, 95% CI: 1.389\u201312.503). Conclusion: These findings suggest that integrating clinical and pathological parameters enhances the prognostic accuracy of NDRD in patients with diabetes, enabling timely therapeutic interventions to mitigate complications in high-risk cases.<\/jats:p>","DOI":"10.1159\/000552662","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:04:44Z","timestamp":1780329884000},"page":"564-573","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Features and Outcomes of Nondiabetic Renal Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study"],"prefix":"10.1159","volume":"12","author":[{"given":"Ting","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-9254","authenticated-orcid":false,"given":"Ying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31694-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)32064-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.12.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1602469"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2129459"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01324-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00888-w"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4522"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008047"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2017-000412"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.220877"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000505919"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(82)92451-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2829"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.10.018"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01836-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.11.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01878-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02348-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04500511"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.12.019"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112137-20200313-00745"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00915-w"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01190216"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1073"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2025845"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab777"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2110956"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2024816"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1901118"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1607141"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.015"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01554-4"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2019.73.87-91"}],"container-title":["Kidney 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