{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:50:29Z","timestamp":1786467029847,"version":"build-2736575974"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: This study aimed to investigate the association between serum LGALS3BP levels and acute exacerbations, airway inflammation, lung function, and airway remodeling in children with asthma. Methods: A total of 93 children with asthma (57 with stable condition and 36 with acute exacerbation) and 100 healthy controls were enrolled. Pulmonary function tests, markers of allergic and airway inflammation, pro-inflammatory cytokines, and airway remodeling-related biomarkers were also assessed. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed to evaluate the independent factors associated with and the diagnostic performance for acute exacerbations. Results: Serum LGALS3BP levels were significantly higher in children with asthma than in healthy controls and were further elevated during acute exacerbations (all p &lt; 0.001). Increased LGALS3BP levels were independently associated with a higher risk of acute exacerbations (odds ratio = 1.073, 95% confidence interval: 1.003\u20131.147; p = 0.040). ROC analysis demonstrated strong discriminatory performance for identifying exacerbations (AUC = 0.910), with 76.3% sensitivity and 91.0% specificity. Serum LGALS3BP levels showed significant moderate negative correlations with lung function parameters and positive correlations with eosinophil counts, total immunoglobulin E, fractional exhaled nitric oxide, pro-inflammatory cytokines, and airway remodeling markers, including transforming growth factor-\u03b21, matrix metalloproteinases-2, matrix metalloproteinases-9, and stromal cell-derived factor-1\u03b1 (all p &lt; 0.05). Conclusion: Elevated serum LGALS3BP levels are closely associated with acute exacerbations, airway inflammation, impaired lung function, and airway remodeling in pediatric asthma. These findings suggest that LGALS3BP may serve as a promising noninvasive biomarker for disease activity and exacerbation risk.<\/jats:p>","DOI":"10.1159\/000552682","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:55:22Z","timestamp":1782838522000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum Lectin Galactoside-Binding Soluble 3-Binding Protein with Acute Exacerbation, Inflammation, and Airway Remodeling in Pediatric Asthma"],"prefix":"10.1159","author":[{"given":"Haifeng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2205PP"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02865.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.024"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2731"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3049"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0006-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30879-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0307TR"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.047"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7479107"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117534"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3311"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511167103"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-06-449"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2017.1396474"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1335"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01196-2014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h996"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60183-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-018-0047-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03085-w"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00794.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.06.001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200907-067DP"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00259.2013"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040342"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0965OC"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:00:56Z","timestamp":1786464056000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1159\/000552682","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32838275","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}