{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:46:43Z","timestamp":1785775603854,"version":"3.56.0"},"reference-count":72,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Objectives: The aim was to evaluate the therapeutic effects of dehydroepiandrosterone (DHEA) and DT56a (Femarelle\u00ae) on systemic and genitourinary symptoms of menopause in postmenopausal women. Design: A comparative effectiveness research study of seventy postmenopausal women (mean age: 53 years), experiencing postmenopausal symptoms, was designed. Participants: Seventy patients were randomly assigned to receive either DHEA (60 mg\/day) or Femarelle\u00ae (644 mg\/day) for 3 months. Materials, Setting, Methods: Subjects were assessed for serum estradiol, luteinizing hormone, follicle-stimulating hormone, Greene Climacteric Scales Scores, female urinary symptoms, and female sexual function index (FSFI). Results: Both DHEA and Femarelle\u00ae demonstrated comparable efficacy in reducing total Greene Climacteric Scale scores. No significant differences in serum follicle-stimulating hormone and E2 levels were observed between the 2 groups. Within-group analyses showed that DHEA was associated with significant improvements in urinary symptoms (overactive bladder symptom score, urinary distress inventory-6, incontinence impact questionnaire-7, international consultation of incontinence questionnaire, and pelvic organ prolapse distress inventory) and sexual function measures (FSFI domains including desire, arousal, lubrication, orgasm, and satisfaction), whereas Femarelle\u00ae did not show significant changes over the 3-month period. Between-group comparisons of change scores suggested a trend toward greater improvement in the DHEA group; however, these findings should be interpreted with caution, given the exploratory design and limited sample size. Limitations: The absence of testosterone measurements limits the assessment of the androgenic effects of DHEA. Femarelle\u00ae has never been studied for sexual function; our findings are preliminary and require long-term validation. Conclusions: While both DHEA and Femarelle\u00ae were effective in improving climacteric symptoms, DHEA was associated with improvements in genitourinary symptoms in this cohort. However, given the exploratory design and absence of a placebo control, these findings should be interpreted as hypothesis-generating.<\/jats:p>","DOI":"10.1159\/000552775","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:01:34Z","timestamp":1782144094000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Dehydroepiandrosterone versus Femarelle\u00ae on Menopausal Systemic and Genitourinary 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