{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:41:55Z","timestamp":1786725715668,"version":"build-2736575974"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<jats:p>Introduction: Immunoglobulin A (IgA) nephropathy usually occurs after upper respiratory tract infection. The currently widely accepted pathomechanism involves genetic predisposition, formation of galactose-deficient IgA1, and production of autoantibodies against these IgA, ultimately leading to mesangial deposition of immune complexes. Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease with a suspected autoimmune mechanism, although the exact etiology and pathomechanism are not fully understood. To our knowledge, only a few cases with simultaneous occurrence of these two entities have been reported in common literature so far. Case Presentation: A 53-year-old Ethiopian woman presented with a month of postprandial nausea, vomiting, occipital headache, 5 kilogram weight loss and intermittent night sweats. Laboratory examinations revealed hematuria and impaired renal function, histological findings showed acute tubulointerstitial nephritis and glomerulonephritis. Further assessments revealed left-sided anterior uveitis as well as a Helicobacter pylori and Strongyloides infection. We present the case of a middle-aged woman with concurrent IgA nephropathy and TINU syndrome, possibly following a H. pylori and Strongyloides infection. There was rapid and significant improvement of renal disease after glucocorticoid treatment. Conclusion: Further research is needed to elucidate possible causality between IgA nephropathy, TINU syndrome, and the potential trigger factors involved.<\/jats:p>","DOI":"10.1159\/000552832","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:01:26Z","timestamp":1781798486000},"page":"106-112","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous Appearance of Immunoglobulin A Nephropathy and Tubulointerstitial Nephritis and Uveitis Syndrome: A Case Report"],"prefix":"10.1159","volume":"16","author":[{"given":"Andr\u00e1s","family":"Ad\u00e1my","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Br\u00fcgger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Nickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7080225"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01554-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09051209"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfn006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232077"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5414\/CN108139"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-305"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-78"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2020.1772295"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:24:48Z","timestamp":1786724688000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552832","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32687343","asserted-by":"subject"}]},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}