{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:29:10Z","timestamp":1786123750020,"version":"build-2736575974"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Undifferentiated pleomorphic sarcoma (UPS) as a secondary malignancy following adjuvant radiation therapy is rare and typically associated with poor prognosis. PD-1 inhibition has been previously investigated as a possible treatment in this space. Case Presentation: This case presents a 91-year-old male with UPS of the right parotid region, presumed secondary to radiation therapy for cutaneous squamous cell carcinoma. The patient was treated with pembrolizumab immunotherapy and a complete clinical response was achieved, with significant improvement noted on restaging scans. Treatment was well-tolerated despite advanced age and multiple comorbidities. Conclusion: This case demonstrates the efficacy of PD-1 inhibitor therapy in radiation-induced UPS and supports emerging evidence for immunotherapy as a viable treatment option in advanced or unresectable sarcomas, particularly with patients who cannot undergo surgery.<\/jats:p>","DOI":"10.1159\/000552848","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:09:39Z","timestamp":1782842979000},"page":"1130-1137","source":"Crossref","is-referenced-by-count":0,"title":["Complete Response to Pembrolizumab in Radiation-Induced Undifferentiated Pleomorphic Sarcoma of the Face: A Case Report and Review of the Literature"],"prefix":"10.1159","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1285-8632","authenticated-orcid":false,"given":"Ethan Roman","family":"Leoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bonaventure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Kansara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4453-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-025-01349-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(17)30624-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(18)30006-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775761"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002345"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cas.70018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01812-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_432234"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2019.37.15_suppl.11015"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.02.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1008484\/full"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01821-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-20-1899"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01054-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2019.1665977"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.975342\/full"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-24-3485"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:00:59Z","timestamp":1786118459000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552848","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32819912","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}