{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:17:45Z","timestamp":1785827865321,"version":"3.56.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Introduction: Common peroneal nerve palsy, termed \u201cslimmer\u2019s palsy,\u201d is a recognized complication of rapid weight loss. This case series describes 2 patients who developed foot drop following tirzepatide-induced weight loss precipitated by habitual leg crossing. Case Presentations: Peroneal neuropathy secondary to compression from habitual leg crossing developed in 2 male patients during tirzepatide therapy for weight loss. Patient 1 was a 55-year-old with severe hidradenitis suppurativa on multiple immunosuppressive medications who started on tirzepatide and lost 50 pounds over 5 months. Patient 2 was a 71-year-old with insulin resistance who lost 30 pounds over 3 months on tirzepatide. Both patients developed foot drop over 24\u201372 h. Treatment was behavioral modification to avoid leg crossing, supplemented by physical therapy, and, in patient 1, ankle bracing. Foot drop signs resolved over 3 to 4 months. Conclusion: Clinicians prescribing tirzepatide should counsel patients about peroneal nerve palsy risk during rapid weight loss. Patients should avoid prolonged leg crossing. Early recognition enables timely intervention and favorable outcomes.<\/jats:p>","DOI":"10.1159\/000552890","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:03:58Z","timestamp":1780934638000},"page":"364-369","source":"Crossref","is-referenced-by-count":1,"title":["Weight Drop-Foot Drop: A Case Series of Peroneal Nerve Palsy from Leg Crossing after Tirzepatide-Mediated Weight Loss"],"prefix":"10.1159","volume":"18","author":[{"given":"Ann I.","family":"Tanyous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Oren","family":"Levitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-14-00420"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-011-1177-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/nu17111782"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13566-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.06.054"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/23247096241264635"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000004570"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31827172fe"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2019.0347"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318268c8bc"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.08.016"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172634"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2021.09.040"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.5041"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2025.06.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14124247"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001937"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:52Z","timestamp":1785254452000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552890","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32576103","asserted-by":"subject"}]},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]}}}