{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:51:51Z","timestamp":1791305511512,"version":"4.3.1"},"reference-count":12,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Objectives: Postpartum depressive symptoms (PDSs) are a common psychiatric condition with multifactorial aetiology. Haematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have been proposed as indicators of systemic inflammation in mood disorders. This study aimed to investigate the association between these markers and PDSs in a homogeneous sample of first-time mothers. Design: This was a cross-sectional observational study. Participants\/Materials: Ninety-two primiparous women attending a routine 2-week postpartum follow-up were included. Inclusion criteria comprised age \u226518 years, singleton term pregnancy, and attendance at postpartum follow-up. Setting: The review was conducted in a Department of Obstetrics and Gynaecology, Sel\u00e7uk University Faculty of Medicine, T\u00fcrkiye. Methods: Depressive symptoms were assessed using the validated Turkish Edinburgh Postnatal Depression Scale (EPDS), with a cut-off score of \u226512. Complete blood count parameters were analysed, and NLR, PLR, and MLR were calculated. Statistical analyses included independent samples t-tests, Mann-Whitney U tests, chi-square tests, and binary logistic regression analysis. Results: Maternal and neonatal characteristics were comparable between groups. NLR, PLR, and MLR values did not differ significantly between women with and without PDSs. Logistic regression analysis demonstrated that none of these markers were independent predictors of PDSs (all p &gt; 0.05). Limitations: The cross-sectional design precludes causal inference. Inflammatory markers were assessed at a single postpartum time point, and psychosocial factors potentially associated with depressive symptoms were not systematically evaluated. Conclusions: In this study, NLR, PLR, and MLR were not associated with PDSs. These findings suggest that simple blood count-derived ratios may have limited utility as standalone indicators of PDSs.<\/jats:p>","DOI":"10.1159\/000552902","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:00:38Z","timestamp":1787328038000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Blood Count Ratios and Postpartum Depressive Symptoms: Findings from a Homogeneous Sample of First-Time Mothers"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-1739","authenticated-orcid":false,"given":"Ahmet","family":"Bilgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3082-9704","authenticated-orcid":false,"given":"Osman","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rrezearta","family":"Cungu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia Nur","family":"Sa\u011flam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1209-3803","authenticated-orcid":false,"given":"\u015eeyma","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-5092","authenticated-orcid":false,"given":"Cetin","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kulhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2024.152456"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.183.4.279"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.893097"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13562-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.685656"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111101"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-023-01414-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000536559"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-101414-020426"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-004-0770-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105646"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2022.100468"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:31Z","timestamp":1791302491000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":12,"URL":"https:\/\/doi.org\/10.1159\/000552902","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33306432","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}