{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:02:20Z","timestamp":1785430940287,"version":"3.56.0"},"reference-count":87,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"abstract":"<jats:p>Introduction: Elders with essential tremor (ET) are at a heightened risk for incident dementia. Although the consequences of this diagnosis are formidable, we know little about what factors elevate the risk of ET-dementia. We analyzed data from a large, prospective, longitudinal study of cognitive status in an ET cohort to examine whether a range of demographic, lifestyle, and clinical variables contribute to dementia risk. Methods: The cognitive status (normal cognition [NC], mild cognitive impairment [MCI], or dementia) of a baseline sample of 350 ET cases (M age = 79.5 years) was tracked for up to 7.5 years (M follow-up = 4.7 years). Cox proportional hazards regressions identified baseline characteristics that predicted the development of dementia. Results: Older age and greater cognitive impairment at baseline (MCI versus NC) each predicted incident dementia, HR &gt; 1.10, p &lt; 0.0001. Diminished functional abilities (HR = 0.39), greater gait impairment (HR = 1.30), lower confidence in one\u2019s balance skills (HR = 0.98), and more depressive symptoms at baseline (HR = 1.08) further predicted conversion to dementia, all p &lt; 0.006. Neither continuous nor categorical measures of ET onset age predicted incident ET-dementia. Conclusions: These data represent the most comprehensive assessment to date of risk factors for ET-dementia in terms of number of factors studied and cohort size. At least one of these risk factors \u2013 depression \u2013 is modifiable and may offer intervention points to reduce risk of dementia. Older age of ET onset, previously viewed as a risk factor, did not predict incident ET-dementia.<\/jats:p>","DOI":"10.1159\/000552903","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:04:33Z","timestamp":1780934673000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Incident Dementia in a Cohort of Elders with Essential Tremor: A Prospective, Longitudinal Study"],"prefix":"10.1159","author":[{"given":"Diane S.","family":"Berry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan 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