{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:18:00Z","timestamp":1790983080819,"version":"4.1.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm Intest Dis"],"abstract":"<jats:p>Introduction: Mesalamine intolerance occurs in 5\u201310% of patients with ulcerative colitis (UC), while myocarditis is an extremely rare but potentially fatal complication. Optimal UC management after mesalamine-induced myocarditis remains unclear. Case Presentation: A man in his 30s with left-sided UC developed mesalamine-induced myocarditis 3 weeks after treatment initiation, confirmed by elevated troponin T, reduced ejection fraction (23%), and a positive drug-induced lymphocyte stimulation test. Cardiac function improved with corticosteroids; however, UC relapsed during steroid tapering. After multidisciplinary discussion and shared decision-making, upadacitinib was selected considering potential cardiac risk with anti-TNF therapy and the need to minimize corticosteroid exposure. Rapid clinical improvement was observed, and complete mucosal healing (Mayo endoscopic subscore 0) was confirmed at 6-month follow-up colonoscopy. Conclusion: This is the first reported case of UC complicated by mesalamine-induced myocarditis successfully treated with upadacitinib. Janus kinase inhibitors may represent a therapeutic option when conventional biologics are unsuitable in patients with severe mesalamine intolerance.<\/jats:p>","DOI":"10.1159\/000552962","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:00:51Z","timestamp":1781193651000},"page":"295-299","source":"Crossref","is-referenced-by-count":1,"title":["Management of Ulcerative Colitis after Mesalamine-Induced Myocarditis: Successful Treatment with Upadacitinib \u2013 A Case Report"],"prefix":"10.1159","volume":"11","author":[{"given":"Taro","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Kinugasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000527452"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.78208"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1557-z"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytae458"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20099"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.11.023"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00581-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-10-200305200-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109927"}],"container-title":["Inflammatory Intestinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000552962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:00:54Z","timestamp":1785513654000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000552962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000552962","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32614137","asserted-by":"subject"}]},"ISSN":["2296-9403","2296-9365"],"issn-type":[{"value":"2296-9403","type":"print"},{"value":"2296-9365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}