{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:58:40Z","timestamp":1785257920112,"version":"3.55.0"},"reference-count":19,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>Introduction: Ulcerative colitis (UC) is characterized by continuous inflammation extending from the rectum. Even mild inflammation can present prognostic implications when the disease is extensive. Mayo Endoscopic Score (MES) 1 represents increased risk of relapse, hospitalization, and treatment modification, but it is based solely on inflammation intensity, incorporating consideration of neither extent nor localization. Methods: Patients with UC in clinical remission with MES 0 or 1 at the initial endoscopic assessment after induction therapy were enrolled retrospectively and were followed for 2 years. Effects of the inflammation extent on remission maintenance were analyzed retrospectively for patients evaluated as MES 1. We investigated whether all MES 1 inflammation should be treated equally. Results: For the 301 included patients, the remission maintenance rate was significantly higher in the MES 0 group than in the MES 1 group (88.9% vs. 67.3%, p &lt; 0.001). Moreover, MES 1 patients with 1\u20132 inflamed segments had higher remission maintenance rates than those with 3\u20136 inflamed segments (78.4% vs. 45.6%, p &lt; 0.001). A significantly higher remission maintenance rate was found for the MES 0 group than for the MES 1 group with 1\u20132 inflamed segments (88.9% vs. 78.4%, p = 0.037). No significant difference was found between rectal and non-rectal involvement (80.7% vs. 76.5%, p = 0.685). Conclusion: The remission maintenance rate decreases as the extent of MES 1 inflammation increases in patients in remission. Even mild but extensive inflammation may increase the risk of relapse. Treatment strategies should incorporate consideration of the inflammation extent.<\/jats:p>","DOI":"10.1159\/000553050","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:00:57Z","timestamp":1781280057000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Effect of MES 1 Inflammatory Extent on Remission Maintenance in Ulcerative Colitis"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-4267","authenticated-orcid":false,"given":"Mimari","family":"Kanazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-3386","authenticated-orcid":false,"given":"Keiichi","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-1208","authenticated-orcid":false,"given":"Takanao","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-832X","authenticated-orcid":false,"given":"Shunsuke","family":"Kojimahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Masuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-3062","authenticated-orcid":false,"given":"Takeshi","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Haruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Irisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-025-01063-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.83"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2016.1141315"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/a-0869-7619"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309598"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.02.016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406303302601"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.01.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab062"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv158"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308839"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx066"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab069"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2174\/1574887117666220513110705"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otad052"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:57Z","timestamp":1785254457000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1159\/000553050","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32648052","asserted-by":"subject"}]},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]}}}