{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:26:27Z","timestamp":1786123587747,"version":"build-2736575974"},"reference-count":9,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"abstract":"<jats:p>Introduction: Obesity is a major risk factor for obstructive sleep apnea (OSA), and weight loss induced by glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with reductions in the apnea-hypopnea index (AHI). Case Presentation: We report a 35-year-old obese man with severe OSA who received tirzepatide for 12 months during the SURMOUNT-OSA trial. His body mass index decreased from 31.0 to 24.9 kg\/m2, and AHI decreased from 54.8 to 4.4 events\/h. Endotypic traits demonstrated improved upper airway patency, increased compensatory pharyngeal muscle responsiveness, reduced loop gain, and a lower arousal threshold, accompanied by paradoxically longer event duration. Conclusion: This case suggests that tirzepatide improves OSA through weight loss as well as favorable shifts in airway physiology and ventilatory control. GLP-1-based therapy may represent a promising treatment for obesity-related OSA, warranting further mechanistic studies.<\/jats:p>","DOI":"10.1159\/000553125","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:28:14Z","timestamp":1782840494000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Endotypic Trait Responses to 12-Month Tirzepatide Treatment for an Obese Patient with Obstructive Sleep Apnea: A Case Report"],"prefix":"10.1159","author":[{"given":"Yen","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ju","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-0713","authenticated-orcid":false,"given":"Eysteinn","family":"Finnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3n S.","family":"\u00c1g\u00fastsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Wen","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae280"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2404881"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707-1435oc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa168"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.06.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02151.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202408-1523ed"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12090224"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:01:08Z","timestamp":1786118468000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":9,"URL":"https:\/\/doi.org\/10.1159\/000553125","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32819909","asserted-by":"subject"}]},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}