{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:50:27Z","timestamp":1786467027952,"version":"build-2736575974"},"reference-count":39,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) share histopathology but differ in clinical presentation, disease course, and treatment patterns. This study aimed to compare clinical characteristics, treatments, outcomes, and prognostic factors between LPP and FFA. Methods: A retrospective cohort study was conducted at Sheba Medical Center, Israel (2010\u20132023). Patients with LPP or FFA followed for \u22651 year were included. Remission was categorized as early (\u226412 months) or late (&gt;12 months). Results: A total of 141 patients were included (81 LPP, 60 FFA). FFA showed greater female predominance (96.7% vs. 80.2%, p = 0.004), older age at presentation (56.9 \u00b1 12.2 vs. 49.1 \u00b1 14.1 years, p = 0.0008) and higher postmenopausal proportion (81.8% vs. 44.4%, p = 0.004). LPP patients more frequently reported pain (50.6% vs. 6.7%) and pruritus (82.7% vs. 36.7%) (both p &lt; 0.00001). Cumulative remission was higher in FFA than in LPP (68.3% vs. 45.7%, p = 0.022), whereas early remission rates and time to remission were similar (22.8 \u00b1 17.6 vs. 22.9 \u00b1 20.5 months, p = 0.98). Relapse rates were similar during treatment (22.0% vs. 16.2%, p = 0.59) and after discontinuation (29.3% vs. 27.0%, p = 0.83). Early remission was predicted by mild baseline severity in LPP (OR: 4.24), and by rural residence (OR: 7.00) and statin use (OR: 3.85) in FFA; tetracycline treatment was inversely associated (OR: 0.21). For late remission in LPP, older age at first visit was positively associated (OR: 1.06\/year), whereas Ashkenazi Jewish ethnicity was inversely associated (OR: 0.33). Conclusion: FFA had higher cumulative remission than LPP despite similar time to remission and relapse rates, with distinct remission predictors.<\/jats:p>","DOI":"10.1159\/000553195","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:07:05Z","timestamp":1782230825000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Insights and Prognostic Factors in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Retrospective Cohort Study"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-7140","authenticated-orcid":false,"given":"Anna","family":"Lyakhovitsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Zilbermintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Jaworowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Galili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Barzilai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.09.058"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.3540"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13112"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02507.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17780"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18854"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1651019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00630-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.1445"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.08.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164947"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.42465"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106765"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0122-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115129"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000534364"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000538355"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01695.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.02.028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-024-00912-w"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00424-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.126"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.062"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.08.086"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12479"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15372"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15517"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14287"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13785"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12264"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.038"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.911944"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1516407"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13996"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17216"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2025.106121"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115644"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:00:53Z","timestamp":1786464053000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1159\/000553195","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32759796","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}