{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:11:18Z","timestamp":1789661478769,"version":"4.0.1"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<jats:p>Introduction: Stroke induces structural brain disruption, accelerating cognitive decline. Using data from the Framingham Heart Study (FHS), we sought to separate aging-only vs. aging plus stroke atrophy rates and its cognitive correlates. Methods: We included cognitively intact FHS participants with first incident stroke. We include pre- and post-index MRIs in both stroke cases and matched controls (2:1), allowing us to estimate aging-only versus aging plus stroke atrophy rates. We computed annualized rates of change in brain volume metrics and cognitive decline, adjusting for relevant factors. Results: We included 45 stroke cases (67.8 \u00b1 10.3 years, 17 (38%) female). Compared to controls, accelerated ipsilesional brain atrophy (adjusted \u0394 = \u22122.39 mm3\/year, p &lt; 0.001) and white matter hyperintensity progression (adjusted \u0394 = 0.71 mm3\/year, p = 0.003) were observed. Voxel-based analysis revealed maximal atrophy subcortically. Accelerated atrophy correlated with global cognition and executive function decline among stroke survivors but not controls. Discussion: This paired-MRI study provides preliminary evidence that stroke modestly accelerates ipsilesional atrophy, predominantly in subcortical regions plausibly linked to processing-speed decline. These findings are hypothesis-generating and require validation in larger prospective studies before firm conclusions can be drawn.<\/jats:p>","DOI":"10.1159\/000553203","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:01:49Z","timestamp":1784908909000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Stroke-Related Acceleration of Brain Atrophy beyond Aging in the Framingham Study: Paired Pre- and Post-MRI Evidence and Cognitive Associations"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-0036","authenticated-orcid":false,"given":"Vasileios-Arsenios","family":"Lioutas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyacinth 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Rafael","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Beiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003587"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030256"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12301"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001502"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75074-w"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021981"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.754204"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.41.3.279"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv337"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.683426"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000150668.58689.f2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2012.2220153"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200109000-00023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/03610730490484380"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.09.036"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028143"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu101"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19831583"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12404"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1516-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305815"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/0891988719862630"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160939"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.633255"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-00988-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016044"}],"container-title":["Cerebrovascular 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