{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:31:01Z","timestamp":1787157061521,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"abstract":"<jats:p>Introduction: Sarcopenia is common in older adults, with distinct features in non-obese individuals. This study developed and validated a nomogram to predict sarcopenia risk specifically in non-obese older adults.\nMethods: Data from 1,654 CHARLS participants were used for model development and internal validation, and 263 NHANES participants for external validation. LASSO regression selected predictors. A nomogram was constructed and assessed using AUC (discrimination), calibration curves (accuracy), and decision curve analysis (clinical utility).\nResults: Seven variables were included in the final nomogram: age, sex, BMI, hemoglobin (Hb), difficulty rising from a chair, history of falls, and basic living ability. The model demonstrated excellent discrimination, with an AUC of 0.88 (95% CI: 0.86-0.90) in the training set. Performance remained robust in the internal (AUC 0.89, 95% CI: 0.85-0.92) and external (AUC 0.94, 95% CI: 0.91-0.97) validation sets. In the sex-stratified analysis, age, BMI, BUN, liver diseases, and basic living ability were included in the male model (AUC: 0.95, 95% CI: 0.93-0.97). For females, age, BMI, creatinine (Cr), difficulty running 1 km, and basic living ability were included (AUC: 0.83, 95% CI: 0.79-0.87). All models demonstrated good calibration and clinical utility.\nConclusion: This study established an effective and simple prediction model for sarcopenia in non-obese older adults. This nomogram can serve as a valuable clinical tool for the early identification and proactive management of sarcopenia in this specific population.<\/jats:p>","DOI":"10.1159\/000553306","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:01:08Z","timestamp":1787155268000},"page":"1-18","source":"Crossref","is-referenced-by-count":0,"title":["construction and evaluation of sarcopenia risk prediction model for non-obese older adults"],"prefix":"10.1159","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,19]]},"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:01:08Z","timestamp":1787155268000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000553306","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33277548","asserted-by":"subject"}]},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}