{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:41:45Z","timestamp":1786552905661,"version":"build-2736575974"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis Extra"],"abstract":"<jats:p>Introduction: Stroke is often followed by vascular cognitive impairment and vascular dementia, the most feared complications of stroke. However, understanding of post-stroke cognitive impairment remains limited. Methods: Rates, risks, and routes to reduce vascular dementia is an observational cohort study of post-stroke cognition. Patients with haemorrhagic or ischaemic stroke, or transient ischaemic attack, were recruited within 6 weeks of stroke from hospitals across the UK. Consent was obtained from patients with capacity or from relatives\/friends in those without capacity. The primary outcome is dementia rate and its severity at 2 years assessed using a 7-level ordinal cognition outcome. Final dementia rate will be compared in those with mild stroke\/TIA (worst NIHSS \u22647) versus severe stroke (NIHSS &gt;7). Secondary outcomes will include cognitive impairment, function, mood and quality of life, and predictors of cognitive impairment at 1 and 2 years. Data are shown as number (%), median (interquartile range [IQR]), or mean (standard deviation [SD]). Results: We recruited 2,441 patients from 50 hospitals. Of these, 2,432 (99.6%) had a qualifying event of stroke or TIA. The mean age was 68.2 years (SD 13.5), females 979 (40.3%), ethnic minority 170 (7.0%), NIHSS \u22647.1962 (80.7%), onset to recruitment 5 days (IQR 3\u201313) and diagnosis ICH 192 (7.9%), ischaemic stroke 2,097 (86.2%), TIA 143 (5.9%). The distribution of cognition at baseline (within 6 weeks of onset) was normal 1,300 (53.5%), minor neurocognitive disorder \u2013 single domain 351 (14.4%), minor neurocognitive disorder \u2013 multi-domain 263 (10.8%), major neurocognitive disorder \u2013 mild 387 (15.9%), major neurocognitive disorder \u2013 moderate 108 (4.4%), and major neurocognitive disorder \u2013 severe 23 (0.1%). Participants with more severe stroke were recruited later (8 [IQR 3\u201317] vs. 5 [2\u201311] days, p &lt; 0.001), less likely to have capacity (86.3% vs. 96.8%, p &lt; 0.001) and more likely to have had an intracerebral haemorrhage (12.0% vs. 6.8%, p &lt; 0.001). Conclusion: We provide baseline data with the statistical analysis plan in the supplementary material. The data highlight the substantial under-appreciated cognitive burden of stroke, even in the first few days and weeks after onset.<\/jats:p>","DOI":"10.1159\/000553355","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:00:44Z","timestamp":1782748844000},"page":"221-239","source":"Crossref","is-referenced-by-count":0,"title":["Rates, Risks, and Routes to Reduce Vascular Dementia: A UK-Wide Multicentre Prospective Observational Cohort Study of Cognition after Stroke \u2013 Baseline Data and Statistical Analysis Plan (ISRCTN18274006)"],"prefix":"10.1159","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-5132","authenticated-orcid":false,"given":"Philip M.","family":"Bath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-9945","authenticated-orcid":false,"given":"Ellen 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