{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:31:28Z","timestamp":1786512688911,"version":"build-2736575974"},"reference-count":28,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>Objective: This study aimed to investigate the relationship between vitamin D receptor gene polymorphism and vitamin D levels with asthma severity, control level, and exacerbation status in asthmatic patients. Subjects and Methods: Over a 6-month period, 162 patients diagnosed with asthma and 85 healthy volunteers were prospectively evaluated. Blood samples were analyzed for vitamin D receptor gene polymorphism by PCR and periostin by ELISA. Results: Among the study participants, 163 were females and 84 were males. The median value of vitamin D in the patient group was significantly lower at 13.95 (3.5\u201333) compared to 17 (6.1\u201339.9) in the control group (p = 0.003). A significant positive correlation was found between Vitamin D and Asthma Control Test (ACT), eosinophil count, peak expiratory flow (PEF, %) (r: 0.18\u20130.25, p &lt; 0.05). When VDR gene polymorphism Fok1 and Apa1 alleles in the patient and control groups were examined, they were found to be similar (p &gt; 0.05). However, when VDR gene polymorphism genotypes were analyzed in terms of vitamin D levels, no significant difference was found between Apa1 genotypes (CC, CT, TT). Regression analysis of variables, which are considered to influence vitamin D levels, showed that gender and PEF are independent determinants. Conclusions: In our study, a significant relationship was found between vitamin D levels and asthma severity, asthma control level, and respiratory functions. However, no significant effect of VDR gene polymorphism was detected on the vitamin D levels and asthma.<\/jats:p>","DOI":"10.1159\/000553361","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:22:31Z","timestamp":1783009351000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["The Effect on Vitamin D Levels and VDR Gene Polymorphism on Clinical Outcomes in Asthma"],"prefix":"10.1159","author":[{"given":"G\u00fclden Deniz","family":"Aksu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Sar\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-3535","authenticated-orcid":false,"given":"Mustafa","family":"\u00c7olak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Solmaz Avc\u0131kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmet","family":"\u00c7oban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan Adil","family":"Hi\u015fmio\u011fullar\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuat","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.113750"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00193.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1596OC"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2023-001684"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2021.42.210056"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.01.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111656"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.10.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.6.491"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0663"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu5010111"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu093"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1070808"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14828"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.209"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31823279"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112477"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.02.016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-014-9648-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.46"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-447OC"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2648-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2020.02.003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01286-2020"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.025"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.050"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:10:14Z","timestamp":1786511414000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1159\/000553361","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32855843","asserted-by":"subject"}]},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}