{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:07:44Z","timestamp":1789834064784,"version":"4.0.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of biliary tract cancer; however, reports on conversion surgery following ICI-based therapy for unresectable disease are scarce. Case Presentations: An 83-year-old female was referred to a local hospital for further evaluation after abnormal liver function was detected during a routine health examination. Computed tomography (CT) revealed a 5 cm tumor in segment 4 of the liver, multiple liver metastases in both lobes, and metastasis to lymph node station 8. Biopsy of the tumor confirmed a diagnosis of intrahepatic cholangiocarcinoma, and the disease was determined to be unresectable due to distant metastases. After 10 courses of gemcitabine, cisplatin, and pembrolizumab (GCP) therapy, follow-up CT revealed marked shrinkage of the primary tumor in segment 4 of the liver, liver metastases, and lymph node station 8. Consequently, an extended left hepatectomy with partial resection of segments 6 and 8 was performed. The postoperative course was uneventful, and the patient was discharged on postoperative day 14. Histopathological examination revealed a pathological complete response (pCR). At 4 months postoperatively, the patient was alive without recurrence. Conclusion: Reports of conversion surgery following GCP therapy are scarce, and patients achieving a pCR are extremely rare.<\/jats:p>","DOI":"10.1159\/000553503","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:01:11Z","timestamp":1784649671000},"page":"1343-1355","source":"Crossref","is-referenced-by-count":0,"title":["Pathological Complete Response following Pembrolizumab Combined with Gemcitabine and Cisplatin Therapy for Initially Unresectable Intrahepatic Cholangiocarcinoma: A Case 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