{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:44:48Z","timestamp":1793234688702,"version":"4.5.0"},"reference-count":23,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Physiological postnatal changes in fetal hemoglobin fraction (FHbF) may affect neonatal tissue oxygenation through shifts in the oxyhemoglobin dissociation curve. We examined cross-sectional associations between FHbF and near-infrared spectroscopy (NIRS)-derived tissue oxygenation, and longitudinal associations between within-infant changes in FHbF and cerebral tissue oxygenation (cStO&lt;sub&gt;2&lt;\/sub&gt;) and oxygen extraction (cFTOE) during the first 3 postnatal weeks in neonates without red blood cell transfusions. Methods: This prospective observational study included 25 preterm (median [IQR] gestational age 33.6 [1.6] weeks) and 25 term (39.9 [1.4] weeks) neonates in a tertiary-center neonatal unit. Measurements were performed at T1 (days 2\u20133), T2 (days 5\u201310), and T3 (days 12\u201318). cStO&lt;sub&gt;2&lt;\/sub&gt; was assessed by time-resolved NIRS, peripheral tissue oxygenation by spatially resolved NIRS and peripheral fractional oxygen extraction by venous occlusion. cFTOE was calculated. Total hemoglobin (Hb) and FHbF were measured by co-oximetry. Cross-sectional associations were assessed using Spearman\u2019s rho correlations. Longitudinal trajectories and gestational age-adjusted within-infant change-on-change associations were analyzed using linear mixed-effects models. Results: No significant cross-sectional correlations were identified between FHbF and cerebral or peripheral NIRS-derived variables at any time point. Over time, Hb and cStO&lt;sub&gt;2&lt;\/sub&gt; declined, cFTOE increased, while peripheral oxygenation and extraction remained stable. Within-infant Hb changes were not associated with concurrent cerebral NIRS changes. In contrast, FHbF change was associated with change in cStO&lt;sub&gt;2&lt;\/sub&gt; (T2\u2013T1: \u03b2 per 1% FHbF, \u22120.19; 95% CI \u22120.33 to \u22120.05) and cFTOE (\u03b2 0.22; 95% CI 0.06\u20130.38). Conclusion: Within-infant FHbF decline was associated with increased cStO&lt;sub&gt;2&lt;\/sub&gt; and decreased cFTOE, independent of total Hb.<\/jats:p>","DOI":"10.1159\/000553520","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:00:34Z","timestamp":1783785634000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Postnatal Changes in Fetal Hemoglobin and Tissue Oxygenation in Preterm and Term Neonates: A Prospective Observational Study"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-5264","authenticated-orcid":false,"given":"Ena","family":"Suppan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Suppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-3712","authenticated-orcid":false,"given":"Bernhard","family":"Schwaberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-3487","authenticated-orcid":false,"given":"Christina H.","family":"Wolfsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-6652","authenticated-orcid":false,"given":"Nariae","family":"Baik-Schneditz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pfurtscheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schlatzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6086-4456","authenticated-orcid":false,"given":"Melina","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011643"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107943"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107360"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197106000-00001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31822a36db"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.8.4.045001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/32\/8\/003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.913223"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.01.026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000438450"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.710465"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05631-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000151655"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.089037"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1117\/1.3076193"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198806000-00013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03646-x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197203000-00003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000525847"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.41643"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.163592"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199307000-00004"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:00:50Z","timestamp":1786982450000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":23,"URL":"https:\/\/doi.org\/10.1159\/000553520","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.32963003","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,11]]}}}