{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:31Z","timestamp":1790927671461,"version":"4.1.0"},"reference-count":47,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Early locoregional recurrence in low-risk early-stage breast cancer following mastectomy and adjuvant chemotherapy is a relatively infrequent event. Sufficient empirical evidence is sparse to support commonly accepted explanations relating to inflammation as a recurrence risk factor that precedes and likely promotes cancer recurrence evolution. Case Presentation: Dynamics of circulating tumor cells, tissue change, and low-grade inflammation were recorded in a representative breast cancer survivor follow-up case having relapsed 31 months after treatment completion. Prospective longitudinal testing was conducted based on a cell-based liquid biopsy platform supporting multi-rare cell marker analysis. The study provided evidence for the inflammation theory relating to epithelial tissue inflammation detectable at baseline, steady progression in marker abnormality, and chronic low-grade systemic inflammation appearing in cyclical patterns. Conclusion: Therefore, our observations of persistent inflammation prior to relapse provide deeper insights into pathology progression and contribute to emerging data to support the inflammation hypothesis. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000553558","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:01:09Z","timestamp":1784649669000},"page":"1610-1625","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Low-Grade Inflammation Precedes Early Locoregional Recurrence following Mastectomy in Low-Risk Early-Stage Breast Cancer: A Longitudinal Case 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