{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:59:55Z","timestamp":1790269195921,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>Introduction: Effective removal of protein-bound and middle\/large molecular toxins is essential in maintenance hemodialysis (HD). This study compared the efficacy of high-flux HD combined with KHA130 hemoadsorption (HA) cartridge against hemodiafiltration (HDF) and high-flux HD combined with the HA130 HA cartridge. Methods: Sixty patients were randomized to HDF group (n = 20), HD+HA group (n = 20), and HD+KHA group (n = 20). HD+HA and HD+KHA groups received 2 h of HA followed by additional 2 h of high-flux HD. The HDF group received 4 h of HDF using the post-dilution mode. The primary endpoint was the single-session clearance rate of the protein-bound toxin p-cresyl sulfate (PCS), with a non-inferiority margin set at 10%. Secondary endpoints included clearance of indoxyl sulfate (IS), advanced glycation end products (AGEs), \u03b22-microglobulin (\u03b22-MG), and inflammatory factors. Results: Baseline characteristics were comparable. For the primary endpoint of PCS clearance, HD+KHA was non-inferior to HDF and superior to HD+HA (p &lt; 0.01). Results for secondary endpoints were less consistent: non-inferiority for IS and \u03b22-MG clearance was observed only in unadjusted models, and no non-inferiority was observed for AGEs or inflammatory cytokines. Sensitivity analyses confirmed the robustness of the primary finding. No serious adverse events were reported. Conclusion: In this acute single-session biochemical study, the HD+KHA regimen met the criterion for non-inferiority to HDF and superiority to HD+HA for PCS clearance. However, given the exploratory nature of secondary and subgroup analyses, these findings require confirmation in larger, adequately powered studies with longer follow-up.<\/jats:p>","DOI":"10.1159\/000553597","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:00:41Z","timestamp":1784736041000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of High-Flux Hemodialysis Combined with KHA130 Hemoadsorption versus HA130 Hemoadsorption or Hemodiafiltration for Toxin Clearance"],"prefix":"10.1159","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1333170"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5888\/pcd21.240052"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcs8050172"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.028"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1652718"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000525952"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf116.089"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13255"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2025.106265"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-022-01375-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125747"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103853"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf146"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac082.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14161"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14110779"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.134"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/toxins17080392"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021050681"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.04.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v11i4.27237"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66076"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2024.130519"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcad069.353"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad063c_6760"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14954"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae069.1528"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.70014"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:00:41Z","timestamp":1790265641000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1159\/000553597","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33057923","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}