{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:59:40Z","timestamp":1790269180202,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>OBJECTIVE: To evaluate the clinical efficacy and safety of Yiqi Tongqiao Pill (YQTP) in treating allergic rhinitis (AR) with a Traditional Chinese Medicine (TCM) pattern of Lung-Spleen Qi Deficiency.\nMETHODS: A multicenter, randomized, double-blind, parallel-controlled, phase III clinical trial was conducted. A total of 480 patients with allergic rhinitis were randomly assigned in a 3:1 ratio to a treatment group (oral YQTP, n=360) and a control group (oral low-dose mimic agent, n=119) for a 2-week course. The primary efficacy endpoint was the change from baseline in the Total Nasal Symptom Score (TNSS) after 2 weeks of treatment.\nRESULTS: The Full Analysis Set (FAS) included 479 patients. After 2 weeks of treatment, the reduction in TNSS score in the treatment group (5.79\u00b12.23) was significantly greater than that in the control group (0.84\u00b11.82) (P&lt;0.0001). The treatment group also demonstrated significant superiority over the control group in terms of overall response rate (92.78% vs 10.92%), improvement in TCM syndrome score, quality of life, and speed of symptom relief (all P&lt;0.0001). There was no statistically significant difference in the incidence of adverse events between the two groups, indicating a good safety profile.\nCONCLUSION: YQTP significantly improved nasal symptoms and quality of life over 2 weeks in patients with SAR with the TCM pattern of lung\u2013spleen qi deficiency, with a safety profile comparable to the mimic control.\nTrial registration: Chinese Clinical Trial Registry (ChiCTR-TRC-13003137); http:\/\/www.chictr.org.cn<\/jats:p>","DOI":"10.1159\/000553598","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:00:50Z","timestamp":1790265650000},"page":"1-16","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Yiqi Tongqiao Pill for Allergic Rhinitis With Lung\u2013Spleen Qi Deficiency: A Multicenter Randomized Double-Blind Phase III Trial"],"prefix":"10.1159","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoye","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,24]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000553598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:00:51Z","timestamp":1790265651000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000553598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000553598","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33985924","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}